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We studied the role of cyclic nucleotides in the influence of hydrogen sulfide (H2S) donor, sodium hydrosulfide (NaHS, 200 μM), on motor activity of rat jejunum. NaHS reduced spontaneous and carbachol-induced contractions of rat jejunum segment, which suggests that H2S can act through mechanisms involving muscarinic receptor activation. Against the background of a membrane-penetrating non-hydrolyzable cAMP analogue or under conditions of adenylate cyclase blockade, the inhibitory effect of NaHS on the carbachol-induced contractions was maintained. Against the background of elevated cGMP concentration or guanylate cyclase inhibition, the reduction of carbachol-induced contractions upon exposure to NaHS was less pronounced than in control. It was hypothesized that H2S induces relaxation of carbachol-induced jejunum contractions, affecting protein kinase G targets or activating cGMP synthesis.
D M Gabitova, and
I F Shaidullov, and
G I Sabirullina, and
M U Shafigullin, and
F G Sitdikov, and
G F Sitdikova
June 2012,
The Journal of surgical research,
D M Gabitova, and
I F Shaidullov, and
G I Sabirullina, and
M U Shafigullin, and
F G Sitdikov, and
G F Sitdikova
March 2018,
Biochemical pharmacology,
D M Gabitova, and
I F Shaidullov, and
G I Sabirullina, and
M U Shafigullin, and
F G Sitdikov, and
G F Sitdikova
February 2012,
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract,
D M Gabitova, and
I F Shaidullov, and
G I Sabirullina, and
M U Shafigullin, and
F G Sitdikov, and
G F Sitdikova
July 2012,
Iranian journal of basic medical sciences,
D M Gabitova, and
I F Shaidullov, and
G I Sabirullina, and
M U Shafigullin, and
F G Sitdikov, and
G F Sitdikova
July 2014,
Bulletin of experimental biology and medicine,
D M Gabitova, and
I F Shaidullov, and
G I Sabirullina, and
M U Shafigullin, and
F G Sitdikov, and
G F Sitdikova
October 2020,
Bulletin of experimental biology and medicine,
D M Gabitova, and
I F Shaidullov, and
G I Sabirullina, and
M U Shafigullin, and
F G Sitdikov, and
G F Sitdikova
January 1981,
Archives of environmental health,
D M Gabitova, and
I F Shaidullov, and
G I Sabirullina, and
M U Shafigullin, and
F G Sitdikov, and
G F Sitdikova
January 2014,
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology,
D M Gabitova, and
I F Shaidullov, and
G I Sabirullina, and
M U Shafigullin, and
F G Sitdikov, and
G F Sitdikova
December 2007,
Transplantation proceedings,
D M Gabitova, and
I F Shaidullov, and
G I Sabirullina, and
M U Shafigullin, and
F G Sitdikov, and
G F Sitdikova
January 1980,
Annals of the New York Academy of Sciences,
