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The stimulatory effects of calcium alpha-glycerophosphate (CaG) and Ca2+ on the generation of medullary prostaglandin E2 have been compared. CaG (4mM) was significantly more effective than Ca2+ (4 mM) as a stimulus for prostaglandin E2 release. This effect of CaG was most pronounced in the presence of exogenous phospholipase A2 (0.1 unit/ml). These results suggest that CaG has a more powerful stimulatory effect on prostaglandin E2 formation than Ca2+ because of its high affinity for phospholipase A2.
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