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Kainic acid was injected into the rat striatum and its effects on presumptive striatal cholinergic, GABAergic and somatostatin-containing neurons were examined with three histochemical staining methods. Presumptive cholinergic and GABAergic neurons are damaged to a similar extent, but somatostatin neurons are more sensitive to the neurotoxic effect of kainic acid and are more severely affected.
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