The most common cause of pain in the region of the temporomandibular joint is occluso-muscle imbalance. This results most often from disharmony between the articulation of the teeth and the centric relation of the condyles. Muscle tenderness of palpation indicates that muscle is involved. An examination must then be done to determine the cause of the muscle tenderness. Before the condyle-occlusion relationship can be evaluated, an accurate centric relation must be determined and verified. The condyles are in centric relation when they are in the most superior position possible in the fossae. From that apex of force position, the condyle can travel neither forward nor backward without moving downward. This position can be located with careful bilateral manipulation and then verified if it can resist firm pressure with no tension or tenderness. Until this correct centric relation is located and verified, it is not possible to properly evaluate the occlusal relationship to the temporomandibular joints. If the occlusion is harmonized to a centric related condyle that can resist firm pressure with pressure with no discomfort, there will be no reason for the muscles to protect either the teeth or the joints. If an occlusion is adjusted to a malrelated condylar position, the occluso-muscle imbalance will be perpetuated and often intensified. Centric relation is the starting point of occlusal contact. Incline interferences in excusive movements must also be eliminated and the occlusion must be harmonized to the envelope of function for each patient. If centric relation is not properly located, occlusal interferences will remain regardless of what procedures are used to record or adjust excursive movements.