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Addition of retinoic acid to human promyelocytic leukemia cells results in a dramatic increase in cellular transglutaminase activity. This increase is due to the induction of a specific intracellular transglutaminase, tissue transglutaminase. Retinoic acid-induced expression of tissue transglutaminase is potentiated by analogues of cyclic AMP. The induction of the enzyme can be detected within 6 h of the addition of the retinoid to the cell and results in increases of the enzyme of at least 50-fold. The induction of HL-60 transglutaminase is a specific response of the cells to retinoic acid and is not seen with other agents that induce HL-60 differentiation. We believe that the induction of tissue transglutaminase is a useful index of the early events in retinoid-regulated gene expression in both normal and transformed cells.
P J Davies, and
M P Murtaugh, and
W T Moore, and
G S Johnson, and
D Lucas
September 2002,
Biochemical and biophysical research communications,
P J Davies, and
M P Murtaugh, and
W T Moore, and
G S Johnson, and
D Lucas
February 1998,
Oncogene,
P J Davies, and
M P Murtaugh, and
W T Moore, and
G S Johnson, and
D Lucas
April 1981,
Experientia,
P J Davies, and
M P Murtaugh, and
W T Moore, and
G S Johnson, and
D Lucas
January 2004,
Yao xue xue bao = Acta pharmaceutica Sinica,
P J Davies, and
M P Murtaugh, and
W T Moore, and
G S Johnson, and
D Lucas
October 1996,
Bioscience, biotechnology, and biochemistry,
P J Davies, and
M P Murtaugh, and
W T Moore, and
G S Johnson, and
D Lucas
May 2001,
European journal of pharmacology,
P J Davies, and
M P Murtaugh, and
W T Moore, and
G S Johnson, and
D Lucas
September 1989,
Biochemical and biophysical research communications,
P J Davies, and
M P Murtaugh, and
W T Moore, and
G S Johnson, and
D Lucas
September 1985,
Cancer research,
P J Davies, and
M P Murtaugh, and
W T Moore, and
G S Johnson, and
D Lucas
May 1980,
Proceedings of the National Academy of Sciences of the United States of America,
P J Davies, and
M P Murtaugh, and
W T Moore, and
G S Johnson, and
D Lucas
December 1989,
Shi yan sheng wu xue bao,
