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The role of prostaglandins as mediators of the inhibitory effect of somatostatin on gastric acid secretion has been evaluated in conscious and anesthetized rats. The effect of somatostatin on bethanechol-stimulated gastric acid secretion was determined with or without indomethacin pretreatment. Prostaglandin synthesis inhibition (less than 90%) by indomethacin was verified with PGE2-generation assay on gastric mucosal tissue. In both conscious and anesthetized rats somatostatin significantly inhibited the stimulated acid output in the control and indomethacin pretreated groups. The present findings do not support a role for prostaglandins in the inhibition of gastric acid secretion by somatostatin in the rat.
M H Mogard, and
G L Kauffman, and
M Pehlevanian, and
E Golanska, and
J D Elashoff, and
J H Walsh
January 1983,
Science (New York, N.Y.),
M H Mogard, and
G L Kauffman, and
M Pehlevanian, and
E Golanska, and
J D Elashoff, and
J H Walsh
May 1969,
The Journal of pharmacy and pharmacology,
M H Mogard, and
G L Kauffman, and
M Pehlevanian, and
E Golanska, and
J D Elashoff, and
J H Walsh
October 1976,
Pharmacological research communications,
M H Mogard, and
G L Kauffman, and
M Pehlevanian, and
E Golanska, and
J D Elashoff, and
J H Walsh
September 1978,
Metabolism: clinical and experimental,
M H Mogard, and
G L Kauffman, and
M Pehlevanian, and
E Golanska, and
J D Elashoff, and
J H Walsh
July 1982,
International journal of clinical pharmacology, therapy, and toxicology,
M H Mogard, and
G L Kauffman, and
M Pehlevanian, and
E Golanska, and
J D Elashoff, and
J H Walsh
January 1978,
Revista de medicina interna, neurologe, psihiatrie, neurochirurgie, dermato-venerologie. Medicina interna,
M H Mogard, and
G L Kauffman, and
M Pehlevanian, and
E Golanska, and
J D Elashoff, and
J H Walsh
December 1988,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
M H Mogard, and
G L Kauffman, and
M Pehlevanian, and
E Golanska, and
J D Elashoff, and
J H Walsh
October 1967,
The American journal of digestive diseases,
M H Mogard, and
G L Kauffman, and
M Pehlevanian, and
E Golanska, and
J D Elashoff, and
J H Walsh
April 1986,
Agents and actions,
M H Mogard, and
G L Kauffman, and
M Pehlevanian, and
E Golanska, and
J D Elashoff, and
J H Walsh
December 1976,
European journal of pharmacology,
