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The in vitro and in vivo responses of integumental chromatophores to alpha-MSH and a related analogue, [Nle4, D-Phe7] -alpha-MSH, were studied in a number of vertebrate species: the teleost, Lebistes reticulatus; the amphibians, Rana pipiens, R. catesbeiana, Xenopus laevis, Bufo alvarius, and B. cognatus; the lizard, Anolis carolinensis; the rattlesnake, Crotalus atrox. The alpha-melanotropin analogue was a superpotent agonist in the in vitro frog (R. pipiens, R. catesbeiana) and lizard (A. carolinensis) skin bioassays. In all species studied, the analogue exhibited ultraprolonged melanotropic activity, both in vitro and in vivo. This melanotropin and related analogues should prove useful in the study of numerous physiological processes, particularly when prolonged melanotropic activity is desired.
M E Hadley, and
J H Mieyr, and
B E Martin, and
A M Castrucci, and
V J Hruby, and
T K Sawyer, and
E A Powers, and
K R Rao
December 1988,
Investigational new drugs,
M E Hadley, and
J H Mieyr, and
B E Martin, and
A M Castrucci, and
V J Hruby, and
T K Sawyer, and
E A Powers, and
K R Rao
January 1985,
Endocrine research,
M E Hadley, and
J H Mieyr, and
B E Martin, and
A M Castrucci, and
V J Hruby, and
T K Sawyer, and
E A Powers, and
K R Rao
October 2000,
Photochemistry and photobiology,
M E Hadley, and
J H Mieyr, and
B E Martin, and
A M Castrucci, and
V J Hruby, and
T K Sawyer, and
E A Powers, and
K R Rao
March 1984,
Life sciences,
M E Hadley, and
J H Mieyr, and
B E Martin, and
A M Castrucci, and
V J Hruby, and
T K Sawyer, and
E A Powers, and
K R Rao
January 1989,
Pigment cell research,
M E Hadley, and
J H Mieyr, and
B E Martin, and
A M Castrucci, and
V J Hruby, and
T K Sawyer, and
E A Powers, and
K R Rao
March 1993,
Pharmacology, biochemistry, and behavior,
M E Hadley, and
J H Mieyr, and
B E Martin, and
A M Castrucci, and
V J Hruby, and
T K Sawyer, and
E A Powers, and
K R Rao
February 1997,
Nuclear medicine and biology,
M E Hadley, and
J H Mieyr, and
B E Martin, and
A M Castrucci, and
V J Hruby, and
T K Sawyer, and
E A Powers, and
K R Rao
June 1986,
Biochemical and biophysical research communications,
M E Hadley, and
J H Mieyr, and
B E Martin, and
A M Castrucci, and
V J Hruby, and
T K Sawyer, and
E A Powers, and
K R Rao
June 1988,
European journal of pharmacology,
M E Hadley, and
J H Mieyr, and
B E Martin, and
A M Castrucci, and
V J Hruby, and
T K Sawyer, and
E A Powers, and
K R Rao
October 1985,
Cancer research,
