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One hundred sixty-three patients who were given synthetic LH-RH therapeutically underwent monitoring of serum IgG anti-LH-RH antibodies. Five of the patients showed specific binding to antibodies. Development of anti-LH-RH antibodies was not limited to those patients with a congenital deficiency of LH-RH. Urticarial responses occurred in four patients, only one of whom had IgG antibodies. Patients who had IgG antibodies or an urticarial response underwent monitoring of their serum IgE anti-LH-RH antibodies, but none had a positive binding response. The refractory state which has been reported in patients in whom similar antibodies to LH-RH develop was not invariably observed among these patients.
J L Meakin, and
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C E Martin
February 1981,
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J L Meakin, and
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J L Meakin, and
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J L Meakin, and
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J L Meakin, and
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J L Meakin, and
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J L Meakin, and
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J L Meakin, and
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J L Meakin, and
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J L Meakin, and
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