-transparent.png){kind=logo}
[125I-Tyr]Somatostatin [( 125I-Tyr]SRIH) binding was found in 11 GH-secreting pituitary adenomas [Kd = 0.46 +/- 0.15 (+/- SE) nM; maximum binding, 165 +/- 35 fmol/mg protein). This binding was specific, since it was displaced by somatostatin-14 (SRIH-14), N-Tyr-SRIH-14, and SRIH-28. In contrast, a number of peptides and drugs not structurally related to SRIH, such as bombesin, dopamine, LHRH, met-enkephalin, naloxone, neurotensin, secretin, substance P, TRH, or vasoactive intestinal peptide, did not affect [125I-Tyr]SRIH binding. [125I-Tyr]SRIH specific binding also was found in PRL-secreting pituitary adenomas. The kinetic characteristics of the specific binding were similar to those of GH-secreting adenomas. However, maximal binding was one quarter that of GH-secreting adenomas (37 +/- 9 fmol/mg protein). In contrast, nonsecreting (chromophobe) tumors were devoid of any specific binding. Finally, in acromegaly, the density of [125I-Tyr]SRIH-binding sites in the adenomas was negatively correlated with plasma GH levels before surgery (r = -0.80). This suggests that somatostatinergic control is involved in GH secretion in acromegalic patients.
E Moyse, and
M Le Dafniet, and
J Epelbaum, and
P Pagesy, and
F Peillon, and
C Kordon, and
A Enjalbert
June 1990,
Journal of neurosurgery,
E Moyse, and
M Le Dafniet, and
J Epelbaum, and
P Pagesy, and
F Peillon, and
C Kordon, and
A Enjalbert
March 1989,
The American journal of pathology,
E Moyse, and
M Le Dafniet, and
J Epelbaum, and
P Pagesy, and
F Peillon, and
C Kordon, and
A Enjalbert
May 1976,
Neurologia medico-chirurgica,
E Moyse, and
M Le Dafniet, and
J Epelbaum, and
P Pagesy, and
F Peillon, and
C Kordon, and
A Enjalbert
August 1992,
The Indian journal of medical research,
E Moyse, and
M Le Dafniet, and
J Epelbaum, and
P Pagesy, and
F Peillon, and
C Kordon, and
A Enjalbert
July 1979,
Comptes rendus des seances de l'Academie des sciences. Serie D, Sciences naturelles,
E Moyse, and
M Le Dafniet, and
J Epelbaum, and
P Pagesy, and
F Peillon, and
C Kordon, and
A Enjalbert
April 2003,
Endocrine,
E Moyse, and
M Le Dafniet, and
J Epelbaum, and
P Pagesy, and
F Peillon, and
C Kordon, and
A Enjalbert
January 2014,
Patient preference and adherence,
E Moyse, and
M Le Dafniet, and
J Epelbaum, and
P Pagesy, and
F Peillon, and
C Kordon, and
A Enjalbert
May 1993,
Acta endocrinologica,
E Moyse, and
M Le Dafniet, and
J Epelbaum, and
P Pagesy, and
F Peillon, and
C Kordon, and
A Enjalbert
November 1983,
The Western journal of medicine,
E Moyse, and
M Le Dafniet, and
J Epelbaum, and
P Pagesy, and
F Peillon, and
C Kordon, and
A Enjalbert
May 2007,
Clinical cancer research : an official journal of the American Association for Cancer Research,
