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The bioavailability of griseofulvin was followed in twelve healthy volunteers by measuring the urinary excretion of the major metabolite 6-demethylgriseolfulvin, after each volunteer had ingested one 500 mg griseofulvin tablet under (1) fasting conditions, (2) immediately after a typical low-fat and (3) high-fat Nigerian meals. An increase of about 70 and 120% absorption occurred with the ingestion of the low-fat and high-fat meals respectively compared to the fasting state (P less than 0.01). The maximum excretion rates of the free metabolite (Vmax.) were also significantly increased (P less than 0.01) following consumption of low and high fat meals. Our results thus suggest that the higher the fat content of the meals the higher the enhancement of the bioavailability of griseofulvin in man.
F A Ogunbona, and
I F Smith, and
O S Olawoye
August 1980,
Journal of pharmacokinetics and biopharmaceutics,
F A Ogunbona, and
I F Smith, and
O S Olawoye
January 1982,
The Journal of international medical research,
F A Ogunbona, and
I F Smith, and
O S Olawoye
June 1975,
Research communications in chemical pathology and pharmacology,
F A Ogunbona, and
I F Smith, and
O S Olawoye
September 1975,
Current therapeutic research, clinical and experimental,
F A Ogunbona, and
I F Smith, and
O S Olawoye
October 1981,
Die Pharmazie,
F A Ogunbona, and
I F Smith, and
O S Olawoye
September 1975,
Current therapeutic research, clinical and experimental,
F A Ogunbona, and
I F Smith, and
O S Olawoye
September 1985,
International journal of clinical pharmacology, therapy, and toxicology,
F A Ogunbona, and
I F Smith, and
O S Olawoye
January 1991,
Die Pharmazie,
F A Ogunbona, and
I F Smith, and
O S Olawoye
July 1970,
JAMA,
F A Ogunbona, and
I F Smith, and
O S Olawoye
August 1995,
European journal of clinical nutrition,
