-transparent.png){kind=logo}
Using a combined technique of immunocytochemistry and [3H]thymidine autoradiography, we have determined the "birth-date" of opioid peptide containing neurons in three hypothalamic nuclei. These include proopiomelanocortin neurons (indicated by ACTH immunoreactivity) in the arcuate nucleus, dynorphin A neurons in the supraoptic nucleus, and [Leu]enkephalin neurons in the periventricular nucleus. Arcuate proopiomelanocortin neurons were born very early in embryonic development, with peak heavy [3H]thymidine nuclear labelling occurring on embryonic day E12. Supraoptic dynorphin A neurons were also labelled relatively early (peak at E13). By contrast, [Leu]enkephalin neurons in the periventricular nucleus exhibited peak heavy nuclear labelling on day E14. The results indicate a differential genesis of these three opioid peptide containing neuronal groups in three different hypothalamic nuclei.
H Khachaturian, and
N E Alessi, and
M E Lewis, and
N Munfakh, and
M D Fitzsimmons, and
S J Watson
March 1985,
Neuroendocrinology,
H Khachaturian, and
N E Alessi, and
M E Lewis, and
N Munfakh, and
M D Fitzsimmons, and
S J Watson
May 1996,
Brain research. Developmental brain research,
H Khachaturian, and
N E Alessi, and
M E Lewis, and
N Munfakh, and
M D Fitzsimmons, and
S J Watson
February 1988,
The Journal of comparative neurology,
H Khachaturian, and
N E Alessi, and
M E Lewis, and
N Munfakh, and
M D Fitzsimmons, and
S J Watson
July 1988,
The Journal of comparative neurology,
H Khachaturian, and
N E Alessi, and
M E Lewis, and
N Munfakh, and
M D Fitzsimmons, and
S J Watson
December 1985,
Neuroscience letters,
H Khachaturian, and
N E Alessi, and
M E Lewis, and
N Munfakh, and
M D Fitzsimmons, and
S J Watson
January 1985,
Peptides,
H Khachaturian, and
N E Alessi, and
M E Lewis, and
N Munfakh, and
M D Fitzsimmons, and
S J Watson
November 1984,
Brain research,
H Khachaturian, and
N E Alessi, and
M E Lewis, and
N Munfakh, and
M D Fitzsimmons, and
S J Watson
April 1975,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
H Khachaturian, and
N E Alessi, and
M E Lewis, and
N Munfakh, and
M D Fitzsimmons, and
S J Watson
November 1966,
Archivum histologicum Japonicum = Nihon soshikigaku kiroku,
H Khachaturian, and
N E Alessi, and
M E Lewis, and
N Munfakh, and
M D Fitzsimmons, and
S J Watson
February 1986,
The Journal of neuroscience : the official journal of the Society for Neuroscience,
