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Acetyl-CoA-carboxylase is isolated and purified to a homogeneous state from the chicken liver with alimentary lipogenesis stimulation. Under the action of nicotinic acid in vivo the specific enzyme activity is shown to decrease considerably followed by some variations in its properties. According to the results obtained during ultracentrifugation and PAAG electrophoresis nicotinic acid causes partial enzyme deaggregation with simultaneous increase of its phosphorylation. The latter is accompanied by a rise in the content of phosphate labile to alkali on acetyl-CoA-carboxylase subunits. Nicotinic acid in vivo has practically no effect on acetyl-CoA-carboxylase synthesis and decay rate. Its inhibiting action is induced by stimulation of enzyme phosphorylation.
S V Pozharun, and
A G Khalmuradov, and
A I Fomenko, and
L N Khustochka, and
S P Stepanenko
January 1985,
Ukrainskii biokhimicheskii zhurnal (1978),
S V Pozharun, and
A G Khalmuradov, and
A I Fomenko, and
L N Khustochka, and
S P Stepanenko
January 1985,
Ukrainskii biokhimicheskii zhurnal (1978),
S V Pozharun, and
A G Khalmuradov, and
A I Fomenko, and
L N Khustochka, and
S P Stepanenko
June 1979,
Biokhimiia (Moscow, Russia),
S V Pozharun, and
A G Khalmuradov, and
A I Fomenko, and
L N Khustochka, and
S P Stepanenko
January 1980,
Ukrainskii biokhimicheskii zhurnal (1978),
S V Pozharun, and
A G Khalmuradov, and
A I Fomenko, and
L N Khustochka, and
S P Stepanenko
January 1977,
The Journal of biological chemistry,
S V Pozharun, and
A G Khalmuradov, and
A I Fomenko, and
L N Khustochka, and
S P Stepanenko
August 1981,
The Journal of biological chemistry,
S V Pozharun, and
A G Khalmuradov, and
A I Fomenko, and
L N Khustochka, and
S P Stepanenko
January 1981,
Methods in enzymology,
S V Pozharun, and
A G Khalmuradov, and
A I Fomenko, and
L N Khustochka, and
S P Stepanenko
June 1980,
Proceedings of the National Academy of Sciences of the United States of America,
S V Pozharun, and
A G Khalmuradov, and
A I Fomenko, and
L N Khustochka, and
S P Stepanenko
February 1988,
The Journal of biological chemistry,
S V Pozharun, and
A G Khalmuradov, and
A I Fomenko, and
L N Khustochka, and
S P Stepanenko
October 1990,
European journal of biochemistry,
