BACKGROUND One of the biggest disadvantages of dental amalgam is that gaining its ultimate strength is a slow process. The use of a rapid-setting amalgam with high early compressive strength could be a better option in preventing early fractures in pediatric dentistry. The aim of this study was to determine the effect of diode laser irradiation on compressive strength of dental amalgam. METHODS A case-control study was performed on 180 amalgam samples made at the Tehran Dental Material Research Center in 2014. Fifteen and thirty minute compressive strength of regular setting and fast setting amalgams were measured as control. In case groups, the samples were irradiated by 810nm diode laser with power of 1 and 2 watt and in pulsed and continuous mode, and compressive strength was measured after 15 and 30 minutes. Statistical analysis was performed with SPSS 18 using one and two way ANOVA and Scheffe multiple comparisons test and p<0.05 was considered significant. RESULTS Numerous kinds of laser irradiation led to a significant increase in compressive strength compared to regular setting control groups. Fifteen minutes-compressive strength of regular-setting amalgam irradiated by 2 watt laser was significantly more than fast-setting control group (p<0.05). CONCLUSIONS Irradiation by 810nm diode laser can significantly increase the compressive strength of dental amalgam especially in the first 15 minutes.