-transparent.png){kind=logo}
We studied the efficacy and side effects of the H1-antihistamine astemizole in perennial rhinitis. We also defined subgroups of responders and examined the added effect of a steroid spray. Fifty-five adults completed a 10- to 14-week controlled trial. Astemizole reduced the number of sneezes to 41% (p less than 0.001) and the number of nose blowings to 55% (p less than 0.001) of the placebo values. The added use of beclomethasone dipropionate caused a further reduction to 14% (p less than 0.001) and 37% (p less than 0.05), respectively. Nasal blockage was only marginally affected by the antihistamine, but it was reduced to 64% by the steroid spray (p less than 0.001). "Sneezers" responded better to the antihistamine than "blockers," with "nose blowers" in an intermediate position. The effect was equal in allergic and nonallergic patients. Astemizole was completely nonsedative but increased appetite and body weight. An open 1-year study of 17 patients demonstrated that astemizole maintained its efficacy and that further weight gain did not occur. It is concluded that astemizole is a highly effective nonsedative H1-antihistamine suitable for continuous therapy of perennial rhinitis.
J A Wihl, and
B N Petersen, and
L N Petersen, and
G Gundersen, and
K Bresson, and
N Mygind
January 1987,
Annals of allergy,
J A Wihl, and
B N Petersen, and
L N Petersen, and
G Gundersen, and
K Bresson, and
N Mygind
January 1987,
American journal of otolaryngology,
J A Wihl, and
B N Petersen, and
L N Petersen, and
G Gundersen, and
K Bresson, and
N Mygind
December 1990,
The Journal of allergy and clinical immunology,
J A Wihl, and
B N Petersen, and
L N Petersen, and
G Gundersen, and
K Bresson, and
N Mygind
May 1998,
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery,
J A Wihl, and
B N Petersen, and
L N Petersen, and
G Gundersen, and
K Bresson, and
N Mygind
January 2012,
Mediators of inflammation,
J A Wihl, and
B N Petersen, and
L N Petersen, and
G Gundersen, and
K Bresson, and
N Mygind
January 2004,
Allergy,
J A Wihl, and
B N Petersen, and
L N Petersen, and
G Gundersen, and
K Bresson, and
N Mygind
April 2006,
The Journal of otolaryngology,
J A Wihl, and
B N Petersen, and
L N Petersen, and
G Gundersen, and
K Bresson, and
N Mygind
June 1988,
Hospital practice (Office ed.),
J A Wihl, and
B N Petersen, and
L N Petersen, and
G Gundersen, and
K Bresson, and
N Mygind
November 2019,
Allergy and asthma proceedings,
J A Wihl, and
B N Petersen, and
L N Petersen, and
G Gundersen, and
K Bresson, and
N Mygind
January 1999,
American journal of rhinology,
