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Two patients with local heat urticaria were examined for evidence of histamine release and for changes in mast cell morphology after local heat challenge. Both patients demonstrated significant release of histamine into the draining venous blood in the challenged arm. Biopsy specimens revealed mucosal edema after 30 min, followed by a mononuclear, perivascular infiltrate by 6 hr, and increasing in intensity by 24 hr. Degranulated mast cells were observed by electron microscopy. Heat challenge was repeated after treatment with hydroxyzine, cimetidine, or a combination of both drugs. Neither hydroxyzine nor cimetidine alone affected the clinical response to challenge, but both drugs together completely abolished the clinical response. In addition, the combination of both drugs taken regularly completely prevented symptoms. This observation suggests that histamine is one of the major mediators of this disorder and that both H1 and H2 receptors are operative.
R B Irwin, and
P Lieberman, and
M M Friedman, and
M Kaliner, and
R Kaplan, and
G Bale, and
G Treadwell, and
T J Yoo
October 1981,
The Journal of allergy and clinical immunology,
R B Irwin, and
P Lieberman, and
M M Friedman, and
M Kaliner, and
R Kaplan, and
G Bale, and
G Treadwell, and
T J Yoo
August 1983,
The Journal of dermatology,
R B Irwin, and
P Lieberman, and
M M Friedman, and
M Kaliner, and
R Kaplan, and
G Bale, and
G Treadwell, and
T J Yoo
July 1981,
Archives of dermatology,
R B Irwin, and
P Lieberman, and
M M Friedman, and
M Kaliner, and
R Kaplan, and
G Bale, and
G Treadwell, and
T J Yoo
September 1978,
Clinical allergy,
R B Irwin, and
P Lieberman, and
M M Friedman, and
M Kaliner, and
R Kaplan, and
G Bale, and
G Treadwell, and
T J Yoo
January 1985,
Archives of dermatology,
R B Irwin, and
P Lieberman, and
M M Friedman, and
M Kaliner, and
R Kaplan, and
G Bale, and
G Treadwell, and
T J Yoo
March 1977,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
R B Irwin, and
P Lieberman, and
M M Friedman, and
M Kaliner, and
R Kaplan, and
G Bale, and
G Treadwell, and
T J Yoo
January 1990,
Dermatologische Monatschrift,
R B Irwin, and
P Lieberman, and
M M Friedman, and
M Kaliner, and
R Kaplan, and
G Bale, and
G Treadwell, and
T J Yoo
March 1983,
Scandinavian journal of gastroenterology,
R B Irwin, and
P Lieberman, and
M M Friedman, and
M Kaliner, and
R Kaplan, and
G Bale, and
G Treadwell, and
T J Yoo
September 1982,
Klinische Wochenschrift,
R B Irwin, and
P Lieberman, and
M M Friedman, and
M Kaliner, and
R Kaplan, and
G Bale, and
G Treadwell, and
T J Yoo
June 1983,
Zeitschrift fur Hautkrankheiten,
