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A series of analogues related to helenalin demonstrated moderate capability for inhibiting the growth of murine P-388 lymphocytic leukemia cells in vivo and in vitro. The growth inhibition correlated with suppression of both DNA and protein synthesis in P-388 cells. The inhibition of protein synthesis occurred at a relatively low concentration and appeared to occur at the level of initiation. The suppression of DNA synthesis in P-388 cells correlated positively with inhibition of inosine 5'-monophosphate dehydrogenase activity. Although nuclear and alpha DNA polymerase activities were suppressed by certain analogues, the inhibition of the polymerases did not correlate positively with DNA synthesis inhibition and, furthermore, the magnitude of suppression of DNA polymerase activity did not appear to be sufficient to account for the observed suppression of DNA synthesis in P-388 cells.
I H Hall, and
W L Williams, and
S G Chaney, and
C J Gilbert, and
D J Holbrook, and
O Muraoka, and
H Kiyokawa, and
K H Lee
November 1982,
Journal of pharmaceutical sciences,
I H Hall, and
W L Williams, and
S G Chaney, and
C J Gilbert, and
D J Holbrook, and
O Muraoka, and
H Kiyokawa, and
K H Lee
March 1982,
Journal of pharmaceutical sciences,
I H Hall, and
W L Williams, and
S G Chaney, and
C J Gilbert, and
D J Holbrook, and
O Muraoka, and
H Kiyokawa, and
K H Lee
July 1979,
Journal of pharmaceutical sciences,
I H Hall, and
W L Williams, and
S G Chaney, and
C J Gilbert, and
D J Holbrook, and
O Muraoka, and
H Kiyokawa, and
K H Lee
December 1982,
Journal of pharmaceutical sciences,
I H Hall, and
W L Williams, and
S G Chaney, and
C J Gilbert, and
D J Holbrook, and
O Muraoka, and
H Kiyokawa, and
K H Lee
February 1982,
Journal of pharmaceutical sciences,
I H Hall, and
W L Williams, and
S G Chaney, and
C J Gilbert, and
D J Holbrook, and
O Muraoka, and
H Kiyokawa, and
K H Lee
July 1979,
Journal of pharmaceutical sciences,
I H Hall, and
W L Williams, and
S G Chaney, and
C J Gilbert, and
D J Holbrook, and
O Muraoka, and
H Kiyokawa, and
K H Lee
October 1981,
Journal of pharmaceutical sciences,
I H Hall, and
W L Williams, and
S G Chaney, and
C J Gilbert, and
D J Holbrook, and
O Muraoka, and
H Kiyokawa, and
K H Lee
April 1982,
Journal of pharmaceutical sciences,
I H Hall, and
W L Williams, and
S G Chaney, and
C J Gilbert, and
D J Holbrook, and
O Muraoka, and
H Kiyokawa, and
K H Lee
August 1978,
Journal of medicinal chemistry,
I H Hall, and
W L Williams, and
S G Chaney, and
C J Gilbert, and
D J Holbrook, and
O Muraoka, and
H Kiyokawa, and
K H Lee
January 1986,
Archivum immunologiae et therapiae experimentalis,
