BIOMAT Database Logo BIOMAT Database Logo

[Innate lymphoid cells]. 2017

Adeline Crinier, and Charlotte Viant, and Mathilde Girard-Madoux, and Éric Vivier
Aix Marseille Université, CNRS, Inserm, CIML, Marseille, France.

Innate Lymphoid Cells (ILC) are tissue-resident effector lymphocytes that differ from the B and T lymphocytes subsets since they lack specific antigen receptors derived from gene rearrangements. They can be divided into two groups, cytotoxic ILC (NK cells) which are dependent on the transcription factors Eomes and T-bet and produce IFN-γ, and helper-like ILC (ILC1, ILC2, ILC3) which are dependent on T-bet, GATA-3 or RORγT and produce IFN-γ, IL-5/IL-13 or IL-17/IL-22 respectively. Although they were described recently, ILC are the subject of a large number of studies that characterize their role as one of the first effectors of the innate immune response as well as in the development of a wide number of inflammatory disorders.

UI MeSH Term Description Entries
D007113 Immunity, Innate The capacity of a normal organism to remain unaffected by microorganisms and their toxins. It results from the presence of naturally occurring ANTI-INFECTIVE AGENTS, constitutional factors such as BODY TEMPERATURE and immediate acting immune cells such as NATURAL KILLER CELLS. Immunity, Native,Immunity, Natural,Immunity, Non-Specific,Resistance, Natural,Innate Immune Response,Innate Immunity,Immune Response, Innate,Immune Responses, Innate,Immunity, Non Specific,Innate Immune Responses,Native Immunity,Natural Immunity,Natural Resistance,Non-Specific Immunity
D007694 Killer Cells, Natural Bone marrow-derived lymphocytes that possess cytotoxic properties, classically directed against transformed and virus-infected cells. Unlike T CELLS; and B CELLS; NK CELLS are not antigen specific. The cytotoxicity of natural killer cells is determined by the collective signaling of an array of inhibitory and stimulatory CELL SURFACE RECEPTORS. A subset of T-LYMPHOCYTES referred to as NATURAL KILLER T CELLS shares some of the properties of this cell type. NK Cells,Natural Killer Cells,Cell, NK,Cell, Natural Killer,Cells, NK,Cells, Natural Killer,Killer Cell, Natural,NK Cell,Natural Killer Cell
D008214 Lymphocytes White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS. Lymphoid Cells,Cell, Lymphoid,Cells, Lymphoid,Lymphocyte,Lymphoid Cell
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D016131 Lymphocyte Subsets A classification of lymphocytes based on structurally or functionally different populations of cells. Lymphocyte Subpopulations,Lymphocyte Subpopulation,Lymphocyte Subset,Subpopulation, Lymphocyte,Subpopulations, Lymphocyte,Subset, Lymphocyte,Subsets, Lymphocyte

Related Publications

Adeline Crinier, and Charlotte Viant, and Mathilde Girard-Madoux, and Éric Vivier
Innate lymphoid cells. Innate lymphoid cells: a new paradigm in immunology.
May 2015, Science (New York, N.Y.),
Adeline Crinier, and Charlotte Viant, and Mathilde Girard-Madoux, and Éric Vivier
Human innate lymphoid cells.
July 2014, Blood,
Adeline Crinier, and Charlotte Viant, and Mathilde Girard-Madoux, and Éric Vivier
SnapShot: innate lymphoid cells.
September 2013, Immunity,
Adeline Crinier, and Charlotte Viant, and Mathilde Girard-Madoux, and Éric Vivier
Why Innate Lymphoid Cells?
June 2018, Immunity,
Adeline Crinier, and Charlotte Viant, and Mathilde Girard-Madoux, and Éric Vivier
HiJAKing Innate Lymphoid Cells?
January 2017, Frontiers in immunology,
Adeline Crinier, and Charlotte Viant, and Mathilde Girard-Madoux, and Éric Vivier
Human innate lymphoid cells.
November 2016, The Journal of allergy and clinical immunology,
Adeline Crinier, and Charlotte Viant, and Mathilde Girard-Madoux, and Éric Vivier
Human innate lymphoid cells.
November 2016, Immunology letters,
Adeline Crinier, and Charlotte Viant, and Mathilde Girard-Madoux, and Éric Vivier
Innate lymphoid cells in secondary lymphoid organs.
May 2016, Immunological reviews,
Adeline Crinier, and Charlotte Viant, and Mathilde Girard-Madoux, and Éric Vivier
ID'ing innate and innate-like lymphoid cells.
September 2014, Immunological reviews,
Adeline Crinier, and Charlotte Viant, and Mathilde Girard-Madoux, and Éric Vivier
Immunity without innate lymphoid cells.
October 2016, Nature immunology,
Copied contents to your clipboard!