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All-Union Research technological Institute of Antibiotics and Medical Enzymes, Leningrad. Institute of Epidemiology, Virology and medical parasitology, Ministry of Health of the Armenian SSR. The effect of polyenic antibiotics made in the USSR on development of E. histolytica and E. moshkovski was studied. The following antibiotics were used: levorin and its derivatives, mycoheptin, amphotericin B, amphoglucamine and nystatin. The antibiotics were compared with emetine and metronidazole. Some drugs of the imidazole group were also included into the study. On the whole 15 drugs were tested for their antiamebic activity. All the polyenic antibiotics showed a high antiamebic activity. Levorin and its derivatives were the most active. Their MICs ranged from 0.1 to 5.38 micrograms/ml. The most active of the new imidazoles was 100 times less effective than sodium levorin. The studies show that the polyenic antibiotics have an antiamebic activity and a broad antiprotozoal spectrum.
L K Liubimova, and
K O Ovnanian, and
L N Ivanova
August 1973,
Antibiotiki,
L K Liubimova, and
K O Ovnanian, and
L N Ivanova
January 1971,
Antibiotiki,
L K Liubimova, and
K O Ovnanian, and
L N Ivanova
October 1991,
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic],
L K Liubimova, and
K O Ovnanian, and
L N Ivanova
January 1966,
Mikrobiologiia,
L K Liubimova, and
K O Ovnanian, and
L N Ivanova
May 1971,
Cancer research,
L K Liubimova, and
K O Ovnanian, and
L N Ivanova
January 1965,
Bulletin of the World Health Organization,
L K Liubimova, and
K O Ovnanian, and
L N Ivanova
January 1994,
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic],
L K Liubimova, and
K O Ovnanian, and
L N Ivanova
August 1969,
American journal of clinical pathology,
L K Liubimova, and
K O Ovnanian, and
L N Ivanova
January 1997,
Archives of medical research,
L K Liubimova, and
K O Ovnanian, and
L N Ivanova
February 1977,
Biokhimiia (Moscow, Russia),
