-transparent.png){kind=logo}
Effects of nipradilol (K-351) on cardiac performance and myocardial oxygen consumption were investigated in anesthetized open-chest dogs. Nipradilol 0.1 mg/kg i.v. induced falls in systolic and diastolic aortic blood pressure and left ventricular pressure, and decreases in cardiac output, coronary sinus outflow, left ventricular dP/dt and heart rate. Stroke volume was transiently increased and left ventricular stroke work index was significantly decreased, while left ventricular mechanical efficiency was not significantly changed. Myocardial oxygen consumption was significantly decreased. Total peripheral vascular resistance and coronary vascular resistance were persistently increased. Left ventricular enddiastolic pressure was not significantly changed. These results suggest that nipradilol has a possible antianginal property through a decrease in myocardial oxygen consumption due to a fall in aortic blood pressure and a decrease in heart rate.
M Sakanashi, and
K Noguchi, and
S Takeo, and
H Ito, and
Y Miyamoto, and
T Kato
September 1984,
Archives internationales de pharmacodynamie et de therapie,
M Sakanashi, and
K Noguchi, and
S Takeo, and
H Ito, and
Y Miyamoto, and
T Kato
November 1981,
Japanese heart journal,
M Sakanashi, and
K Noguchi, and
S Takeo, and
H Ito, and
Y Miyamoto, and
T Kato
January 1987,
Journal of cardiovascular pharmacology,
M Sakanashi, and
K Noguchi, and
S Takeo, and
H Ito, and
Y Miyamoto, and
T Kato
May 1989,
Zhongguo yao li xue bao = Acta pharmacologica Sinica,
M Sakanashi, and
K Noguchi, and
S Takeo, and
H Ito, and
Y Miyamoto, and
T Kato
November 1985,
Archives internationales de pharmacodynamie et de therapie,
M Sakanashi, and
K Noguchi, and
S Takeo, and
H Ito, and
Y Miyamoto, and
T Kato
September 1984,
European journal of pharmacology,
M Sakanashi, and
K Noguchi, and
S Takeo, and
H Ito, and
Y Miyamoto, and
T Kato
January 1985,
Journal of cardiovascular pharmacology,
M Sakanashi, and
K Noguchi, and
S Takeo, and
H Ito, and
Y Miyamoto, and
T Kato
July 1987,
Zhongguo yao li xue bao = Acta pharmacologica Sinica,
M Sakanashi, and
K Noguchi, and
S Takeo, and
H Ito, and
Y Miyamoto, and
T Kato
January 1986,
Scandinavian journal of thoracic and cardiovascular surgery,
M Sakanashi, and
K Noguchi, and
S Takeo, and
H Ito, and
Y Miyamoto, and
T Kato
July 1997,
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,
