Rapamycin enhances the anti-angiogenesis and anti-proliferation ability of YM155 in oral squamous cell carcinoma. 2017

Kong-Liang Li, and Yu-Fan Wang, and Jia-Ruo Qin, and Feng Wang, and Yong-Tao Yang, and Li-Wu Zheng, and Ming-Hua Li, and Jie Kong, and Wei Zhang, and Hong-Yu Yang
1 Department of Oral and Maxillofacial Surgery, Peking University Shenzhen Hospital, Shenzhen, China.

YM155, a small molecule inhibitor of survivin, has been studied in many tumors. It has been shown that YM155 inhibited oral squamous cell carcinoma through promoting apoptosis and autophagy and inhibiting proliferation. It was found that YM155 also inhibited the oral squamous cell carcinoma-mediated angiogenesis through the inactivation of the mammalian target of rapamycin pathway. Rapamycin, a mammalian target of rapamycin inhibitor, played an important role in the proliferation and angiogenesis of oral squamous cell carcinoma cell lines. In our study, cell proliferation assay, transwell assay, tube formation assay, and western blot assay were used to investigate the synergistic effect of rapamycin on YM155 in oral squamous cell carcinoma. Either in vitro or in vivo, rapamycin and YM155 exerted a synergistic effect on the inhibition of survivin and vascular endothelial growth factor through mammalian target of rapamycin pathway. Overall, our results revealed that low-dose rapamycin strongly promoted the sensitivity of oral squamous cell carcinoma cell lines to YM155.

UI MeSH Term Description Entries
D007093 Imidazoles Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. Chemically reduced ones include IMIDAZOLINES and IMIDAZOLIDINES. Distinguish from 1,2-diazole (PYRAZOLES).
D009062 Mouth Neoplasms Tumors or cancer of the MOUTH. Cancer of Mouth,Mouth Cancer,Oral Cancer,Oral Neoplasms,Cancer of the Mouth,Neoplasms, Mouth,Neoplasms, Oral,Cancer, Mouth,Cancer, Oral,Cancers, Mouth,Cancers, Oral,Mouth Cancers,Mouth Neoplasm,Neoplasm, Mouth,Neoplasm, Oral,Oral Cancers,Oral Neoplasm
D009285 Naphthoquinones Naphthalene rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups. Naphthalenediones,Naphthazarins,Naphthoquinone
D009389 Neovascularization, Pathologic A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions. Angiogenesis, Pathologic,Angiogenesis, Pathological,Neovascularization, Pathological,Pathologic Angiogenesis,Pathologic Neovascularization,Pathological Angiogenesis,Pathological Neovascularization
D002294 Carcinoma, Squamous Cell A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed) Carcinoma, Epidermoid,Carcinoma, Planocellular,Carcinoma, Squamous,Squamous Cell Carcinoma,Carcinomas, Epidermoid,Carcinomas, Planocellular,Carcinomas, Squamous,Carcinomas, Squamous Cell,Epidermoid Carcinoma,Epidermoid Carcinomas,Planocellular Carcinoma,Planocellular Carcinomas,Squamous Carcinoma,Squamous Carcinomas,Squamous Cell Carcinomas
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000077022 Survivin An apoptosis inhibitory protein that contains a single baculoviral IAP repeat (BIR) domain. It associates with MICROTUBULES and functions to regulate cell proliferation as a component of the chromosome passage protein complex (CPC), performing essential roles for localization of the complex, chromosome alignment, segregation during MITOSIS and CYTOKINESIS, and assembly of the MITOTIC SPINDLE. It is expressed by fetal kidney and liver cells and highly expressed in ADENOCARCINOMA and high-grade LYMPHOMA. BIRC5 Protein,Baculoviral IAP Repeat-containing Protein 5,Baculoviral IAP Repeat containing Protein 5
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000971 Antineoplastic Combined Chemotherapy Protocols The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form. Anticancer Drug Combinations,Antineoplastic Agents, Combined,Antineoplastic Chemotherapy Protocols,Antineoplastic Drug Combinations,Cancer Chemotherapy Protocols,Chemotherapy Protocols, Antineoplastic,Drug Combinations, Antineoplastic,Antineoplastic Combined Chemotherapy Regimens,Combined Antineoplastic Agents,Agent, Combined Antineoplastic,Agents, Combined Antineoplastic,Anticancer Drug Combination,Antineoplastic Agent, Combined,Antineoplastic Chemotherapy Protocol,Antineoplastic Drug Combination,Cancer Chemotherapy Protocol,Chemotherapy Protocol, Antineoplastic,Chemotherapy Protocol, Cancer,Chemotherapy Protocols, Cancer,Combinations, Antineoplastic Drug,Combined Antineoplastic Agent,Drug Combination, Anticancer,Drug Combination, Antineoplastic,Drug Combinations, Anticancer,Protocol, Antineoplastic Chemotherapy,Protocol, Cancer Chemotherapy,Protocols, Antineoplastic Chemotherapy,Protocols, Cancer Chemotherapy
D001343 Autophagy The segregation and degradation of various cytoplasmic constituents via engulfment by MULTIVESICULAR BODIES; VACUOLES; or AUTOPHAGOSOMES and their digestion by LYSOSOMES. It plays an important role in BIOLOGICAL METAMORPHOSIS and in the removal of bone by OSTEOCLASTS. Defective autophagy is associated with various diseases, including NEURODEGENERATIVE DISEASES and cancer. Autophagocytosis,ER-Phagy,Lipophagy,Nucleophagy,Reticulophagy,Ribophagy,Autophagy, Cellular,Cellular Autophagy,ER Phagy

Related Publications

Kong-Liang Li, and Yu-Fan Wang, and Jia-Ruo Qin, and Feng Wang, and Yong-Tao Yang, and Li-Wu Zheng, and Ming-Hua Li, and Jie Kong, and Wei Zhang, and Hong-Yu Yang
May 2012, Molecular carcinogenesis,
Kong-Liang Li, and Yu-Fan Wang, and Jia-Ruo Qin, and Feng Wang, and Yong-Tao Yang, and Li-Wu Zheng, and Ming-Hua Li, and Jie Kong, and Wei Zhang, and Hong-Yu Yang
January 1995, Anticancer research,
Kong-Liang Li, and Yu-Fan Wang, and Jia-Ruo Qin, and Feng Wang, and Yong-Tao Yang, and Li-Wu Zheng, and Ming-Hua Li, and Jie Kong, and Wei Zhang, and Hong-Yu Yang
February 2013, Head & neck,
Kong-Liang Li, and Yu-Fan Wang, and Jia-Ruo Qin, and Feng Wang, and Yong-Tao Yang, and Li-Wu Zheng, and Ming-Hua Li, and Jie Kong, and Wei Zhang, and Hong-Yu Yang
February 2005, Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale,
Kong-Liang Li, and Yu-Fan Wang, and Jia-Ruo Qin, and Feng Wang, and Yong-Tao Yang, and Li-Wu Zheng, and Ming-Hua Li, and Jie Kong, and Wei Zhang, and Hong-Yu Yang
November 2018, Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology,
Kong-Liang Li, and Yu-Fan Wang, and Jia-Ruo Qin, and Feng Wang, and Yong-Tao Yang, and Li-Wu Zheng, and Ming-Hua Li, and Jie Kong, and Wei Zhang, and Hong-Yu Yang
January 2015, Kathmandu University medical journal (KUMJ),
Kong-Liang Li, and Yu-Fan Wang, and Jia-Ruo Qin, and Feng Wang, and Yong-Tao Yang, and Li-Wu Zheng, and Ming-Hua Li, and Jie Kong, and Wei Zhang, and Hong-Yu Yang
March 2010, International journal of oral and maxillofacial surgery,
Kong-Liang Li, and Yu-Fan Wang, and Jia-Ruo Qin, and Feng Wang, and Yong-Tao Yang, and Li-Wu Zheng, and Ming-Hua Li, and Jie Kong, and Wei Zhang, and Hong-Yu Yang
July 2015, Pathology oncology research : POR,
Kong-Liang Li, and Yu-Fan Wang, and Jia-Ruo Qin, and Feng Wang, and Yong-Tao Yang, and Li-Wu Zheng, and Ming-Hua Li, and Jie Kong, and Wei Zhang, and Hong-Yu Yang
June 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology,
Kong-Liang Li, and Yu-Fan Wang, and Jia-Ruo Qin, and Feng Wang, and Yong-Tao Yang, and Li-Wu Zheng, and Ming-Hua Li, and Jie Kong, and Wei Zhang, and Hong-Yu Yang
January 2016, Journal of immunology research,
Copied contents to your clipboard!