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In a retrospective study of 60 renal-transplant patients immunosuppressed with cyclosporin no specific clinical features differentiated allograft dysfunction responsive to anti-rejection therapy from dysfunction responsive to reduction in cyclosporin dosage. Histologically, allograft dysfunction responsive to anti-rejection therapy was strongly associated with diffuse interstitial infiltration by mononuclear cells, oedema, and haemorrhage, vascular endothelial-cell proliferation, and infiltration of arterial walls by mononuclear cells. Arteriolar medial hypertrophy and hyalinosis were more commonly found in biopsy specimens from allografts with dysfunction responsive to reduction in cyclosporin dose than in those with dysfunction responsive to anti-rejection therapy and those with stable or improving function. Whole-blood cyclosporin concentrations were significantly lower in patients with dysfunction reversed by anti-rejection therapy than in those with dysfunction reversed by reduction in cyclosporin dose or in those with stable function. There was, however, considerable overlap between these groups, so that individual cyclosporin measurements were of little diagnostic value.
D H Taube, and
G H Neild, and
D G Williams, and
J S Cameron, and
B Hartley, and
C S Ogg, and
C J Rudge, and
K I Welsh
August 1985,
Lancet (London, England),
D H Taube, and
G H Neild, and
D G Williams, and
J S Cameron, and
B Hartley, and
C S Ogg, and
C J Rudge, and
K I Welsh
May 1992,
Transplant international : official journal of the European Society for Organ Transplantation,
D H Taube, and
G H Neild, and
D G Williams, and
J S Cameron, and
B Hartley, and
C S Ogg, and
C J Rudge, and
K I Welsh
May 1986,
Radiology,
D H Taube, and
G H Neild, and
D G Williams, and
J S Cameron, and
B Hartley, and
C S Ogg, and
C J Rudge, and
K I Welsh
January 1989,
Nephron,
D H Taube, and
G H Neild, and
D G Williams, and
J S Cameron, and
B Hartley, and
C S Ogg, and
C J Rudge, and
K I Welsh
April 1991,
Journal of the Formosan Medical Association = Taiwan yi zhi,
D H Taube, and
G H Neild, and
D G Williams, and
J S Cameron, and
B Hartley, and
C S Ogg, and
C J Rudge, and
K I Welsh
September 1981,
Lancet (London, England),
D H Taube, and
G H Neild, and
D G Williams, and
J S Cameron, and
B Hartley, and
C S Ogg, and
C J Rudge, and
K I Welsh
July 2000,
Clinical nephrology,
D H Taube, and
G H Neild, and
D G Williams, and
J S Cameron, and
B Hartley, and
C S Ogg, and
C J Rudge, and
K I Welsh
January 1985,
Journal of nephrology nursing,
D H Taube, and
G H Neild, and
D G Williams, and
J S Cameron, and
B Hartley, and
C S Ogg, and
C J Rudge, and
K I Welsh
January 1994,
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
D H Taube, and
G H Neild, and
D G Williams, and
J S Cameron, and
B Hartley, and
C S Ogg, and
C J Rudge, and
K I Welsh
August 1983,
Lancet (London, England),
