Anti-diabetic xanthones from the bark of Garcinia xanthochymus. 2017

Chi N Nguyen, and Binh T D Trinh, and Toan B Tran, and Le-Thu T Nguyen, and Anna K Jäger, and Lien-Hoa D Nguyen
Natural Product and Medicinal Chemistry Lab, Faculty of Chemistry, VNUHCM-University of Science, 227 Nguyen Van Cu, Ho Chi Minh City, Viet Nam.

An ethyl acetate extract the bark of Garcinia xanthochymus exhibited strong inhibition towards α-glucosidase and PTP1B with IC50 values of 0.3±0.1μg/mL and 2.3±0.4μg/mL, respectively. Chemical constituents of the extract were therefore examined, and two new compounds, xanthochymusxanthones A (1) and B (2), along with ten known xanthones (3-12), were isolated. Their structures were determined using spectroscopic methods, mainly 1D and 2D NMR. Inhibitory activity of the isolated compounds was then tested, and subelliptenone F (12) showed significant effect towards α-glucosidase with IC50 value of 4.1±0.3μM (compared with acarbose, IC50=900.0±3.0μM) whilst xanthochymusxanthone B (2) exhibited remarkable activity towards PTP1B with IC50 value of 8.0±0.6μM (compared with RK682, IC50=4.4±0.3μM).

UI MeSH Term Description Entries
D007004 Hypoglycemic Agents Substances which lower blood glucose levels. Antidiabetic,Antidiabetic Agent,Antidiabetic Drug,Antidiabetics,Antihyperglycemic,Antihyperglycemic Agent,Hypoglycemic,Hypoglycemic Agent,Hypoglycemic Drug,Antidiabetic Agents,Antidiabetic Drugs,Antihyperglycemic Agents,Antihyperglycemics,Hypoglycemic Drugs,Hypoglycemic Effect,Hypoglycemic Effects,Hypoglycemics,Agent, Antidiabetic,Agent, Antihyperglycemic,Agent, Hypoglycemic,Agents, Antidiabetic,Agents, Antihyperglycemic,Agents, Hypoglycemic,Drug, Antidiabetic,Drug, Hypoglycemic,Drugs, Antidiabetic,Drugs, Hypoglycemic,Effect, Hypoglycemic,Effects, Hypoglycemic
D008958 Models, Molecular Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures. Molecular Models,Model, Molecular,Molecular Model
D003920 Diabetes Mellitus A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000520 alpha-Glucosidases Enzymes that catalyze the exohydrolysis of 1,4-alpha-glucosidic linkages with release of alpha-glucose. Deficiency of alpha-1,4-glucosidase may cause GLYCOGEN STORAGE DISEASE TYPE II. Acid Maltase,Lysosomal alpha-Glucosidase,Maltase,Maltases,Maltase-Glucoamylase,Neutral Maltase,Neutral alpha-Glucosidase,alpha-Glucosidase,Lysosomal alpha Glucosidase,Maltase Glucoamylase,Neutral alpha Glucosidase,alpha Glucosidase,alpha Glucosidases,alpha-Glucosidase, Lysosomal,alpha-Glucosidase, Neutral
D044004 Xanthones A group of XANTHENES that contain a 9-keto OXYGEN. Xanthone Derivatives,Derivatives, Xanthone
D054562 Protein Tyrosine Phosphatase, Non-Receptor Type 1 A subtype of non-receptor protein tyrosine phosphatases that includes two distinctive targeting motifs; an N-terminal motif specific for the INSULIN RECEPTOR, and a C-terminal motif specific for the SH3 domain containing proteins. This subtype includes a hydrophobic domain which localizes it to the ENDOPLASMIC RETICULUM. PTPase 1B,PTPase HA2,Protein Tyrosine Phosphatase 1B,Protein-Tyrosine Phosphatase HA2,Protein Tyrosine Phosphatase HA2,Protein Tyrosine Phosphatase, Non Receptor Type 1
D024301 Plant Bark The outer layer of the woody parts of plants. Bark, Plant,Bark, Tree,Tree Bark,Barks, Plant,Barks, Tree,Plant Barks,Tree Barks
D029760 Garcinia A plant genus of the family CLUSIACEAE. Members contain XANTHONES. Gamboge,Gamboges,Garcinias
D065089 Glycoside Hydrolase Inhibitors Compounds that inhibit or block the activity of GLYCOSIDE HYDROLASES such as ALPHA-AMYLASES and ALPHA-GLUCOSIDASES. alpha-Glucosidase Inhibitor,alpha-Glucosidase Inhibitors,Intestinal alpha-Amylase Inhibitors,Pancreatic alpha-Amylase Inhibitors,alpha-Amylase Inhibitors, Pancreatic,Hydrolase Inhibitors, Glycoside,Inhibitor, alpha-Glucosidase,Inhibitors, Glycoside Hydrolase,Inhibitors, Intestinal alpha-Amylase,Inhibitors, Pancreatic alpha-Amylase,Inhibitors, alpha-Glucosidase,Intestinal alpha Amylase Inhibitors,Pancreatic alpha Amylase Inhibitors,alpha Amylase Inhibitors, Pancreatic,alpha Glucosidase Inhibitor,alpha Glucosidase Inhibitors,alpha-Amylase Inhibitors, Intestinal

Related Publications

Chi N Nguyen, and Binh T D Trinh, and Toan B Tran, and Le-Thu T Nguyen, and Anna K Jäger, and Lien-Hoa D Nguyen
November 2003, Chemical & pharmaceutical bulletin,
Chi N Nguyen, and Binh T D Trinh, and Toan B Tran, and Le-Thu T Nguyen, and Anna K Jäger, and Lien-Hoa D Nguyen
September 2008, Yao xue xue bao = Acta pharmaceutica Sinica,
Chi N Nguyen, and Binh T D Trinh, and Toan B Tran, and Le-Thu T Nguyen, and Anna K Jäger, and Lien-Hoa D Nguyen
January 2012, Natural product communications,
Chi N Nguyen, and Binh T D Trinh, and Toan B Tran, and Le-Thu T Nguyen, and Anna K Jäger, and Lien-Hoa D Nguyen
December 2008, Magnetic resonance in chemistry : MRC,
Chi N Nguyen, and Binh T D Trinh, and Toan B Tran, and Le-Thu T Nguyen, and Anna K Jäger, and Lien-Hoa D Nguyen
November 2003, Phytochemistry,
Chi N Nguyen, and Binh T D Trinh, and Toan B Tran, and Le-Thu T Nguyen, and Anna K Jäger, and Lien-Hoa D Nguyen
June 2003, Phytochemistry,
Chi N Nguyen, and Binh T D Trinh, and Toan B Tran, and Le-Thu T Nguyen, and Anna K Jäger, and Lien-Hoa D Nguyen
October 2010, Molecules (Basel, Switzerland),
Chi N Nguyen, and Binh T D Trinh, and Toan B Tran, and Le-Thu T Nguyen, and Anna K Jäger, and Lien-Hoa D Nguyen
November 2003, Phytochemistry,
Chi N Nguyen, and Binh T D Trinh, and Toan B Tran, and Le-Thu T Nguyen, and Anna K Jäger, and Lien-Hoa D Nguyen
May 2007, Chemistry & biodiversity,
Chi N Nguyen, and Binh T D Trinh, and Toan B Tran, and Le-Thu T Nguyen, and Anna K Jäger, and Lien-Hoa D Nguyen
January 2000, Phytochemistry,
Copied contents to your clipboard!