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Several antibiotics have been reported to cause a bleeding diathesis in man, characterized by reduced platelet aggregation. We investigated the effects of several of the penicillins and of moxalactam on the binding of (3H)-methyl-yohimbine to intact human platelets. The (3H)-methyl-yohimbine binding met the criteria for interaction at an alpha2 adrenergic binding site and showed low interindividual variability. Penicillin G, ticarcillin, carbenicillin, piperacillin and moxalactam all inhibited (3H)-methyl-yohimbine binding, but at concentrations far in excess of clinically achievable plasma levels. We conclude that these compounds exert their antiplatelet effects by a mechanism other than competitive inhibition of catecholamine binding.
S E Borst, and
K K Hui, and
M E Conolly
August 1987,
Journal of pharmacobio-dynamics,
S E Borst, and
K K Hui, and
M E Conolly
May 1982,
British journal of pharmacology,
S E Borst, and
K K Hui, and
M E Conolly
June 1983,
Journal of autonomic pharmacology,
S E Borst, and
K K Hui, and
M E Conolly
January 1980,
Advances in prostaglandin and thromboxane research,
S E Borst, and
K K Hui, and
M E Conolly
May 1979,
British journal of pharmacology,
S E Borst, and
K K Hui, and
M E Conolly
January 1981,
Thrombosis research,
S E Borst, and
K K Hui, and
M E Conolly
November 1986,
Journal of pharmacobio-dynamics,
S E Borst, and
K K Hui, and
M E Conolly
August 1985,
Thrombosis and haemostasis,
S E Borst, and
K K Hui, and
M E Conolly
September 1995,
Analytical biochemistry,
S E Borst, and
K K Hui, and
M E Conolly
August 1982,
Biochemical pharmacology,
