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The effects of consecutive administration of 4-monomethylaminoantipyrine, a metabolite of aminopyrine, on the gamma-glutamyltranspeptidase activities of liver, kidney, urine and serum were investigated in rats. On day 5 after repeated treatment, a pronounced increase of gamma-glutamyltranspeptidase activity was seen in the liver homogenate as well as in the hepatic microsomes. Furthermore, simultaneous administration of 4-monomethylaminoantipyrine with phenobarbital increased to the same degree as compared with the single administration of aminopyrine. However, no change in gamma-glutamyltranspeptidase activity was observed in kidney, urine, serum and hepatic cytosolic fractions. Under the same experimental condition, the contents of cytochrome P-450 and b5, NADPH cytochrome c reductase, the activities of aminopyrine N-demethylase and aniline hydroxylase were also enhanced.
K Hoshi, and
N Senda, and
T Igarashi, and
T Satoh, and
K Ueno, and
H Kitagawa
January 1983,
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition,
K Hoshi, and
N Senda, and
T Igarashi, and
T Satoh, and
K Ueno, and
H Kitagawa
July 1984,
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer,
K Hoshi, and
N Senda, and
T Igarashi, and
T Satoh, and
K Ueno, and
H Kitagawa
August 1983,
Toxicology letters,
K Hoshi, and
N Senda, and
T Igarashi, and
T Satoh, and
K Ueno, and
H Kitagawa
August 1971,
The Biochemical journal,
K Hoshi, and
N Senda, and
T Igarashi, and
T Satoh, and
K Ueno, and
H Kitagawa
April 1978,
Experimental and molecular pathology,
K Hoshi, and
N Senda, and
T Igarashi, and
T Satoh, and
K Ueno, and
H Kitagawa
January 1978,
Biochemical pharmacology,
K Hoshi, and
N Senda, and
T Igarashi, and
T Satoh, and
K Ueno, and
H Kitagawa
January 1983,
Molecular pharmacology,
K Hoshi, and
N Senda, and
T Igarashi, and
T Satoh, and
K Ueno, and
H Kitagawa
January 1981,
Annals of nutrition & metabolism,
K Hoshi, and
N Senda, and
T Igarashi, and
T Satoh, and
K Ueno, and
H Kitagawa
August 1989,
Research communications in chemical pathology and pharmacology,
K Hoshi, and
N Senda, and
T Igarashi, and
T Satoh, and
K Ueno, and
H Kitagawa
October 1985,
Cancer letters,
