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Base-catalyzed cascade synthesis of 2,3-dihydrofuro[2,3-b]pyridines and 2,3-dihydro-1H-pyrrolo[2,3-b]pyridines from N-propargylic β-enaminones. 2017
Xiaobing Yang, and
Fangzhong Hu, and
Yang Wang, and
Chiming Yang, and
Xiaomao Zou, and
Jiahui Liu, and
Qichun Zhang
State Key Laboratory and Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China. fzhu@nankai.edu.cn yangchm@nankai.edu.cn.
A novel protocol to prepare multi-substituted dihydrofuropyridine and dihydropyrrolopyridine derivatives from KOH-catalyzed reactions between readily available N-propargylic β-enaminones and arylaldehydes or N-sulfonyl imines has been developed in moderate to good yields.
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