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Antral somatostatin-immunoreactive cells (D cells) were counted pre- and postoperatively in 20 patients with duodenal ulcer and in 8 patients with gastric ulcer. Counts were obtained either over a 2-yr postoperative period (duodenal ulcer patients) at intervals of 0.5, 1, and 2 yr or over a greater than or equal to 4-yr postoperative period (gastric ulcer patients) at intervals of 1-2 yr. In patients with a normal population of gastrin-immunoreactive cells (G cells), the D cells were within the normal range (mean value 0.53% in duodenal ulcer patients and 0.67% in gastric ulcer patients). High G-cell values were accompanied by high D-cell values (e.g., in gastrin-cell hyperplasia) and low G-cell values were accompanied by low D-cell values. The G-cell to D-cell ratio was 8:1 and 6.6:1 in duodenal and gastric ulcer patients, respectively. After selective proximal vagotomy and pyloroplasty, the following observations were made: the relation of number of G cells to number of D cells remained unchanged; the postoperative rise in G-cell population was accompanied by a rise in D-cell population; hypertrophy of the D cells was apparent as was postoperative hyperplasia, with a postoperative increase in D-cell size. Morphologic coupling of the gastrin-somatostatin system in the antrum is assumed. This is constant in ulcer disease both before and after vagotomy.
G E Holle, and
E Buck, and
L Pradayrol, and
E Wünsch, and
F Holle
January 1982,
Zeitschrift fur mikroskopisch-anatomische Forschung,
G E Holle, and
E Buck, and
L Pradayrol, and
E Wünsch, and
F Holle
January 1983,
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G E Holle, and
E Buck, and
L Pradayrol, and
E Wünsch, and
F Holle
January 1980,
Khirurgiia,
G E Holle, and
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L Pradayrol, and
E Wünsch, and
F Holle
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G E Holle, and
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L Pradayrol, and
E Wünsch, and
F Holle
July 1971,
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G E Holle, and
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F Holle
May 1985,
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G E Holle, and
E Buck, and
L Pradayrol, and
E Wünsch, and
F Holle
October 1985,
Vrachebnoe delo,
G E Holle, and
E Buck, and
L Pradayrol, and
E Wünsch, and
F Holle
December 1978,
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G E Holle, and
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L Pradayrol, and
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F Holle
January 1971,
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G E Holle, and
E Buck, and
L Pradayrol, and
E Wünsch, and
F Holle
January 1971,
Acta chirurgica Scandinavica,
