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A DNA Structure Containing AgI -Mediated G:G and C:C Base Pairs. 2017

Hehua Liu, and Fusheng Shen, and Phensinee Haruehanroengra, and Qingqing Yao, and Yunshan Cheng, and Yiqing Chen, and Chun Yang, and Jing Zhang, and Baixing Wu, and Qiang Luo, and Ruixue Cui, and Jixi Li, and Jinbiao Ma, and Jia Sheng, and Jianhua Gan
State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Physiology and Biophysics, School of Life Sciences, Fudan University, Shanghai, 200433, China.

Metal-mediated base pairs have been extensively utilized in many research fields, including genetic-code extension, novel therapeutics development, and nanodevice design. Compared to other cations, AgI is more flexible in pairing with natural base pairs. Herein, we present a DNA structure containing two C-AgI -C pairs and the first reported G-AgI -G pair in a short 8mer DNA strand. This structure not only provides detailed insight into these AgI -mediated base-pairing patterns in DNA, but also represents the first nonhelical DNA structure driven by heavy-metal ions, thus further contributing to the structural diversity of DNA. This unique complex structure is highly sequence-dependent, thus implying functional potentials as a new DNA aptamer that can bind and recognize silver ions. These results not only advance our understanding of the interactions between AgI and nucleobases, but also provide a unique structural component for the rational design of new DNA nanodevices.

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