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A highly purified pilus vaccine prepared from cells of Bacteroides nodosus strain 198 provided a high level of protection against homologous challenge and small, not statistically significant, levels of protection against challenge with 4 other strains each from different serogroups. In a second experiment, a partially purified pilus vaccine from strain 198 induced significant immunity to 1 of 4 heterologous strains which were different from those used in the first experiment. In a third experiment a strain 198 whole cell vaccine produced significant immunity against 3 of 6 heterologous strains used in the first 2 experiments. There was no obvious relationship between the colony type, degree of piliation and level of cross-protection obtained against a particular strain. The results provide further evidence that immunogens associated with, but distinct from, the pilus are involved in cross-protection and that cross-protective antigens are common to some, but not all, strains.
D J Stewart, and
B L Clark, and
J E Peterson, and
D L Emery, and
E F Smith, and
D A Griffiths, and
I J O'Donnell
January 1979,
Comparative immunology, microbiology and infectious diseases,
D J Stewart, and
B L Clark, and
J E Peterson, and
D L Emery, and
E F Smith, and
D A Griffiths, and
I J O'Donnell
February 1985,
The Veterinary record,
D J Stewart, and
B L Clark, and
J E Peterson, and
D L Emery, and
E F Smith, and
D A Griffiths, and
I J O'Donnell
January 1978,
Research in veterinary science,
D J Stewart, and
B L Clark, and
J E Peterson, and
D L Emery, and
E F Smith, and
D A Griffiths, and
I J O'Donnell
February 1979,
The Veterinary record,
D J Stewart, and
B L Clark, and
J E Peterson, and
D L Emery, and
E F Smith, and
D A Griffiths, and
I J O'Donnell
August 1989,
The Veterinary record,
D J Stewart, and
B L Clark, and
J E Peterson, and
D L Emery, and
E F Smith, and
D A Griffiths, and
I J O'Donnell
January 1981,
Research in veterinary science,
D J Stewart, and
B L Clark, and
J E Peterson, and
D L Emery, and
E F Smith, and
D A Griffiths, and
I J O'Donnell
September 1991,
Journal of clinical microbiology,
D J Stewart, and
B L Clark, and
J E Peterson, and
D L Emery, and
E F Smith, and
D A Griffiths, and
I J O'Donnell
April 1984,
Veterinary microbiology,
D J Stewart, and
B L Clark, and
J E Peterson, and
D L Emery, and
E F Smith, and
D A Griffiths, and
I J O'Donnell
November 1970,
Australian veterinary journal,
D J Stewart, and
B L Clark, and
J E Peterson, and
D L Emery, and
E F Smith, and
D A Griffiths, and
I J O'Donnell
March 1987,
Australian veterinary journal,
