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In eastern Thailand, 14 adults with moderately severe falciparum malaria were treated with intravenous amodiaquine dihydrochloride, loading dose 10 mg base/kg infused over 4 h followed by three further intravenous infusions of 5 mg base/kg at 24, 48, and 72 h. All patients were clinically cured--mean fever clearance time 37.8 h (range 24-60), mean parasite clearance time 64.9 h (18-164). There were no serious toxic effects. 33 patients aged over 5 years with uncomplicated falciparum malaria were given oral amodiaquine dihydrochloride (mean total dose 41 mg base/kg over 3 days) combined with erythromycin estolate (mean dose 48 mg base/kg daily for 5 days). 2 patients failed to respond. In the other 31 patients mean fever clearance time was 55.9 h (range 10-104) and mean parasite clearance time was 65.4 h (40-120). In both studies, more than half the patients followed-up had recurrent parasitaemia but reinfection could not be excluded. Parasites isolated from 18 patients were highly resistant to chloroquine in vitro.
S Looareesuwan, and
R E Phillips, and
N J White, and
J Karbwang, and
Y Benjasurat, and
P Attanath, and
D A Warrell
November 1985,
Lancet (London, England),
S Looareesuwan, and
R E Phillips, and
N J White, and
J Karbwang, and
Y Benjasurat, and
P Attanath, and
D A Warrell
January 1988,
Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases,
S Looareesuwan, and
R E Phillips, and
N J White, and
J Karbwang, and
Y Benjasurat, and
P Attanath, and
D A Warrell
November 1983,
The American journal of tropical medicine and hygiene,
S Looareesuwan, and
R E Phillips, and
N J White, and
J Karbwang, and
Y Benjasurat, and
P Attanath, and
D A Warrell
February 2008,
Memorias do Instituto Oswaldo Cruz,
S Looareesuwan, and
R E Phillips, and
N J White, and
J Karbwang, and
Y Benjasurat, and
P Attanath, and
D A Warrell
July 1975,
The American journal of tropical medicine and hygiene,
S Looareesuwan, and
R E Phillips, and
N J White, and
J Karbwang, and
Y Benjasurat, and
P Attanath, and
D A Warrell
December 1991,
Lancet (London, England),
S Looareesuwan, and
R E Phillips, and
N J White, and
J Karbwang, and
Y Benjasurat, and
P Attanath, and
D A Warrell
June 1984,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
S Looareesuwan, and
R E Phillips, and
N J White, and
J Karbwang, and
Y Benjasurat, and
P Attanath, and
D A Warrell
March 1983,
The New England journal of medicine,
S Looareesuwan, and
R E Phillips, and
N J White, and
J Karbwang, and
Y Benjasurat, and
P Attanath, and
D A Warrell
November 1968,
Lancet (London, England),
S Looareesuwan, and
R E Phillips, and
N J White, and
J Karbwang, and
Y Benjasurat, and
P Attanath, and
D A Warrell
May 1980,
The Medical journal of Australia,
