-transparent.png){kind=logo}
During infusion into rats with a portacaval shunt of either ammonium (NH4+) salts alone or NH4+ salts combined with the three branched-chain amino acids (BCAAs) in equimolar quantities, we assessed neurologic function and measured plasma and brain ammonia and amino acid levels and the brain content of amine neurotransmitters and their metabolites. Survival was lengthened and neurologic function was preserved longer in rats receiving BCAAs. Infusion of BCAAs resulted in lower plasma and brain ammonia concentrations compared with rats receiving NH4+ salts alone. Plasma glutamine and alanine levels were higher in rats receiving BCAAs, suggesting increased ammonia detoxification. Loss of neurologic function, regardless of which solution was infused, eventually occurred and corresponded with decreased brain norepinephrine and increased brain alanine levels. These results suggest that BCAAs can protect against hyperammonemia by stimulating the peripheral detoxification of ammonia.
P Rigotti, and
T Jonung, and
J H James, and
L L Edwards, and
J C Peters, and
J E Fischer
January 1986,
JPEN. Journal of parenteral and enteral nutrition,
P Rigotti, and
T Jonung, and
J H James, and
L L Edwards, and
J C Peters, and
J E Fischer
January 1986,
JPEN. Journal of parenteral and enteral nutrition,
P Rigotti, and
T Jonung, and
J H James, and
L L Edwards, and
J C Peters, and
J E Fischer
November 1986,
Journal of neurochemistry,
P Rigotti, and
T Jonung, and
J H James, and
L L Edwards, and
J C Peters, and
J E Fischer
April 1988,
World journal of surgery,
P Rigotti, and
T Jonung, and
J H James, and
L L Edwards, and
J C Peters, and
J E Fischer
January 1985,
European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes,
P Rigotti, and
T Jonung, and
J H James, and
L L Edwards, and
J C Peters, and
J E Fischer
February 1987,
Journal of nutritional science and vitaminology,
P Rigotti, and
T Jonung, and
J H James, and
L L Edwards, and
J C Peters, and
J E Fischer
January 1984,
Nutrition and cancer,
P Rigotti, and
T Jonung, and
J H James, and
L L Edwards, and
J C Peters, and
J E Fischer
February 2019,
Annual review of physiology,
P Rigotti, and
T Jonung, and
J H James, and
L L Edwards, and
J C Peters, and
J E Fischer
January 1988,
Methods in enzymology,
P Rigotti, and
T Jonung, and
J H James, and
L L Edwards, and
J C Peters, and
J E Fischer
January 2017,
Advances in biochemical engineering/biotechnology,
