-transparent.png){kind=logo}
The aim of the present study was to determine whether the liver cytosol detoxication enzymes, glutathione S-transferases (GSTases) as well as gamma-glutamyl transpeptidase (GGT) foci induced by aflatoxin B1 (AFB) were changed by feeding weanling rats diets containing brussels sprouts, a glucosinolate fraction of brussels sprouts (extract), or a non-glucosinolate fraction (residue). All 3 of these diets induced high levels of hepatic GSTase specific activity as compared to purified-basal diet fed control rats. The brussels sprouts and the extract treatments, but not the residue dietary treatment, inhibited hepatic GGT foci induced by AFB. Thus, glucosinolates and non-glucosinolate fractions of brussels sprouts induce hepatic enzymes involved in detoxication mechanisms but the non-glucosinolate compound(s) apparently are not involved in all chemical carcinogen metabolic processes.
C E Godlewski, and
J N Boyd, and
W K Sherman, and
J L Anderson, and
G S Stoewsand
August 2004,
Experimental & molecular medicine,
C E Godlewski, and
J N Boyd, and
W K Sherman, and
J L Anderson, and
G S Stoewsand
August 2021,
Poultry science,
C E Godlewski, and
J N Boyd, and
W K Sherman, and
J L Anderson, and
G S Stoewsand
December 1998,
Experimental & molecular medicine,
C E Godlewski, and
J N Boyd, and
W K Sherman, and
J L Anderson, and
G S Stoewsand
July 1993,
Carcinogenesis,
C E Godlewski, and
J N Boyd, and
W K Sherman, and
J L Anderson, and
G S Stoewsand
November 1996,
Carcinogenesis,
C E Godlewski, and
J N Boyd, and
W K Sherman, and
J L Anderson, and
G S Stoewsand
September 1991,
Toxicology letters,
C E Godlewski, and
J N Boyd, and
W K Sherman, and
J L Anderson, and
G S Stoewsand
January 1981,
Toxicology letters,
C E Godlewski, and
J N Boyd, and
W K Sherman, and
J L Anderson, and
G S Stoewsand
January 1999,
Carcinogenesis,
C E Godlewski, and
J N Boyd, and
W K Sherman, and
J L Anderson, and
G S Stoewsand
January 2003,
Vojnosanitetski pregled,
C E Godlewski, and
J N Boyd, and
W K Sherman, and
J L Anderson, and
G S Stoewsand
June 1990,
Carcinogenesis,
