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The effect of a new octapeptide analogue of somatostatin (SMS 201-995) on blood glucose and gut hormone levels was studied in 10 C-peptide-negative, insulin-dependent diabetic (IDDM) subjects. On separate days, either 50 or 100 micrograms SMS or placebo was s.c. injected simultaneously with an identical insulin dose 30 min before a mixed meal. Postprandial blood glucose decreased after 100 micrograms SMS s.c. within 30 min from 8.9 +/- 0.7 to 7.8 +/- 0.6 mmol/L (P less than 0.001) and remained at similar levels during 180 min. In contrast, postprandial blood glucose concentration increased after placebo from 9.9 +/- 0.8 to 13.8 +/- 0.9 mmol/L (SMS versus placebo P less than 0.001). Plasma glucagon decreased rapidly after SMS to the limit of detection (P less than 0.001) and remained lowered during 180 min; in contrast, glucagon levels increased after the meal during the placebo study (SMS versus placebo P less than 0.001). Plasma growth hormone concentrations were significantly lower after SMS than after placebo (P less than 0.05). SMS abolished completely the postprandial increase in plasma gastrin and pancreatic polypeptide (PP) concentrations. Plasma free fatty acid (FFA) and triglyceride concentrations decreased after SMS, reaching significantly lower levels than after placebo (P less than 0.05 and P less than 0.01), respectively). Plasma SMS concentration increased rapidly after s.c. administration of SMS; its appearance preceded that of plasma free insulin after s.c. insulin injection. Fifty micrograms SMS was similarly effective as 100 micrograms in decreasing blood glucose, triglycerides, glucagon, and gut hormone concentrations.(ABSTRACT TRUNCATED AT 250 WORDS)
G A Spinas, and
A Bock, and
U Keller
December 1986,
Clinical endocrinology,
G A Spinas, and
A Bock, and
U Keller
February 1989,
Harefuah,
G A Spinas, and
A Bock, and
U Keller
December 1986,
The American journal of medicine,
G A Spinas, and
A Bock, and
U Keller
January 1986,
Scandinavian journal of gastroenterology. Supplement,
G A Spinas, and
A Bock, and
U Keller
June 1990,
The British journal of surgery,
G A Spinas, and
A Bock, and
U Keller
September 1987,
Clinical endocrinology,
G A Spinas, and
A Bock, and
U Keller
November 1988,
Surgery,
G A Spinas, and
A Bock, and
U Keller
October 1983,
Metabolism: clinical and experimental,
G A Spinas, and
A Bock, and
U Keller
October 1996,
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology,
G A Spinas, and
A Bock, and
U Keller
November 1986,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
