Biomaterial Database

Risk factors for medication-related osteonecrosis of the jaws: A systematic review. 2018

K McGowan, and T McGowan, and S Ivanovski

School of Dentistry & Oral Health, Griffith University, Southport, QLD, Australia.

The purpose of this study was to identify the patient populations at risk of medication-related osteonecrosis of the jaw (MRONJ) and determine which medical and dental comorbidities are significant risk factors for this disease. An electronic search of Embase, MEDLINE, Cochrane Central Register of Controlled Trials, WHO International Clinical Trials Registry Platform and ProQuest Dissertations and Theses Global was conducted to identify all human studies that reported risk factors for MRONJ. Only a qualitative analysis was performed due to significant heterogeneity in the collected data. The search strategy identified 2872 records, of which 219 studies were eligible for inclusion. A total of 4106 patients with MRONJ were identified, 39 different systemic diseases were implicated, and 14 medical and 11 dental risk factors were reported, although no statistical analysis of the significance of each of these factors was possible. The clinical reach of MRONJ may be wider than anticipated, and more data on the significance of each potential risk factor are needed to guide the identification and management of at-risk patients.

UI	MeSH Term	Description	Entries
D009369	Neoplasms	New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	Benign Neoplasm,Cancer,Malignant Neoplasm,Tumor,Tumors,Benign Neoplasms,Malignancy,Malignant Neoplasms,Neoplasia,Neoplasm,Neoplasms, Benign,Cancers,Malignancies,Neoplasias,Neoplasm, Benign,Neoplasm, Malignant,Neoplasms, Malignant
D010024	Osteoporosis	Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.	Age-Related Osteoporosis,Bone Loss, Age-Related,Osteoporosis, Age-Related,Osteoporosis, Post-Traumatic,Osteoporosis, Senile,Senile Osteoporosis,Osteoporosis, Involutional,Age Related Osteoporosis,Age-Related Bone Loss,Age-Related Bone Losses,Age-Related Osteoporoses,Bone Loss, Age Related,Bone Losses, Age-Related,Osteoporoses,Osteoporoses, Age-Related,Osteoporoses, Senile,Osteoporosis, Age Related,Osteoporosis, Post Traumatic,Post-Traumatic Osteoporoses,Post-Traumatic Osteoporosis,Senile Osteoporoses
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012307	Risk Factors	An aspect of personal behavior or lifestyle, environmental exposure, inborn or inherited characteristic, which, based on epidemiological evidence, is known to be associated with a health-related condition considered important to prevent.	Health Correlates,Risk Factor Scores,Risk Scores,Social Risk Factors,Population at Risk,Populations at Risk,Correlates, Health,Factor, Risk,Factor, Social Risk,Factors, Social Risk,Risk Factor,Risk Factor Score,Risk Factor, Social,Risk Factors, Social,Risk Score,Score, Risk,Score, Risk Factor,Social Risk Factor
D059266	Bisphosphonate-Associated Osteonecrosis of the Jaw	Necrotic jaws or other maxillofacial skeleton necrosis associated with bisphosphonate use (see BISPHOSPHONATES). Injury, dental procedures, and trauma can trigger the necrotic process.	Bisphosphonate Osteonecrosis,Bisphosphonate-Associated Osteonecrosis,Bisphosphonate-Associated Osteonecrosis of the Jaws,Bisphosphonate-Induced Osteonecrosis of the Jaw,Bisphosphonate-Induced Osteonecrosis of the Jaws,Bisphosphonate-Related Osteonecrosis of the Jaw,Osteonecrosis of the Jaw, Bisphosphonate-Associated,Osteonecrosis of the Jaw, Bisphosphonate-Induced,Osteonecrosis of the Jaw, Bisphosphonate-Related,Osteonecrosis of the Jaws, Bisphosphonate-Associated,Osteonecrosis of the Jaws, Bisphosphonate-Induced,Osteonecrosis of the Jaws, Bisphosphonate-Related,Bisphosphonate Associated Osteonecrosis,Bisphosphonate Associated Osteonecrosis of the Jaw,Bisphosphonate Associated Osteonecrosis of the Jaws,Bisphosphonate Induced Osteonecrosis of the Jaw,Bisphosphonate Induced Osteonecrosis of the Jaws,Bisphosphonate Osteonecroses,Bisphosphonate Related Osteonecrosis of the Jaw,Bisphosphonate-Associated Osteonecroses,Osteonecroses, Bisphosphonate,Osteonecroses, Bisphosphonate-Associated,Osteonecrosis of the Jaw, Bisphosphonate Associated,Osteonecrosis of the Jaw, Bisphosphonate Induced,Osteonecrosis of the Jaw, Bisphosphonate Related,Osteonecrosis of the Jaws, Bisphosphonate Associated,Osteonecrosis of the Jaws, Bisphosphonate Induced,Osteonecrosis of the Jaws, Bisphosphonate Related,Osteonecrosis, Bisphosphonate,Osteonecrosis, Bisphosphonate-Associated