On selection in finite populations. 2018

Chai Molina, and David J D Earn
Department of Mathematics and Statistics, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada. chai.molina@gmail.com.

Two major forces shaping evolution are drift and selection. The standard models of neutral drift-the Wright-Fisher (WF) and Moran processes-can be extended to include selection. However, these standard models are not always applicable in practice, and-even without selection-many other drift models make very different predictions. For example, "generalised Wright-Fisher" models (so-called because their first two conditional moments agree with those of the WF process) can yield wildly different absorption times from WF. Additionally, evolutionary stability in finite populations depends only on fixation probabilities, which can be evaluated under less restrictive assumptions than those required to estimate fixation times or more complex population-genetic quantities. We therefore distill the notion of a selection process into a broad class of finite-population, mutationless models of drift and selection (including the WF and Moran processes). We characterize when selection favours fixation of one strategy over another, for any selection process, which allows us to derive finite-population conditions for evolutionary stability independent of the selection process. In applications, the precise details of the selection process are seldom known, yet by exploiting these new theoretical results it is now possible to make rigorously justifiable inferences about fixation of traits.

UI MeSH Term Description Entries
D008390 Markov Chains A stochastic process such that the conditional probability distribution for a state at any future instant, given the present state, is unaffected by any additional knowledge of the past history of the system. Markov Process,Markov Chain,Chain, Markov,Chains, Markov,Markov Processes,Process, Markov,Processes, Markov
D008957 Models, Genetic Theoretical representations that simulate the behavior or activity of genetic processes or phenomena. They include the use of mathematical equations, computers, and other electronic equipment. Genetic Models,Genetic Model,Model, Genetic
D011336 Probability The study of chance processes or the relative frequency characterizing a chance process. Probabilities
D005716 Game Theory Theoretical construct used in applied mathematics to analyze certain situations in which there is an interplay between parties that may have similar, opposed, or mixed interests. In a typical game, decision-making "players," who each have their own goals, try to gain advantage over the other parties by anticipating each other's decisions; the game is finally resolved as a consequence of the players' decisions. Game Theories,Theories, Game,Theory, Game
D005828 Genetics, Population The discipline studying genetic composition of populations and effects of factors such as GENETIC SELECTION, population size, MUTATION, migration, and GENETIC DRIFT on the frequencies of various GENOTYPES and PHENOTYPES using a variety of GENETIC TECHNIQUES. Population Genetics
D012641 Selection, Genetic Differential and non-random reproduction of different genotypes, operating to alter the gene frequencies within a population. Natural Selection,Genetic Selection,Selection, Natural
D055641 Mathematical Concepts Numeric or quantitative entities, descriptions, properties, relationships, operations, and events. Concept, Mathematical,Concepts, Mathematical,Mathematical Concept
D019143 Evolution, Molecular The process of cumulative change at the level of DNA; RNA; and PROTEINS, over successive generations. Molecular Evolution,Genetic Evolution,Evolution, Genetic
D019295 Computational Biology A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets. Bioinformatics,Molecular Biology, Computational,Bio-Informatics,Biology, Computational,Computational Molecular Biology,Bio Informatics,Bio-Informatic,Bioinformatic,Biologies, Computational Molecular,Biology, Computational Molecular,Computational Molecular Biologies,Molecular Biologies, Computational
D040961 Genetic Drift The fluctuation of the ALLELE FREQUENCY from one generation to the next. Evolution, Neutral,Drift, Genetic,Neutral Evolution

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