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The structural requirement of the prostaglandin D2 molecule for binding to the synaptic membrane fraction of rat brain was extensively studied by using various prostaglandin D derivatives. Most strict specificity was found in the structures of the cyclo-pentane ring and the double bond in 13,14-position. The addition and deprivation of the double bond in alpha- and omega-chain, except on 13,14-position, moderately affected the binding. The modification in the carboxyl terminus and omega-chain terminus did not seriously influence the binding. BW 245C and 9-beta-prostaglandin D2, potent agonists for the prostaglandin D2 receptor in the platelet membrane, were almost ineffective. [3H]prostaglandin D2 binding was not affected by the addition of various neuroactive substances to the binding assay mixture. Further, prostaglandin D2 did not affect the known neurotransmitter receptor bindings in the rat brain.
H Tokumoto, and
Y Watanabe, and
A Yamashita, and
Y Arai, and
O Hayaishi
November 1982,
The Journal of biological chemistry,
H Tokumoto, and
Y Watanabe, and
A Yamashita, and
Y Arai, and
O Hayaishi
February 1982,
Scandinavian journal of immunology,
H Tokumoto, and
Y Watanabe, and
A Yamashita, and
Y Arai, and
O Hayaishi
April 1981,
Canadian journal of physiology and pharmacology,
H Tokumoto, and
Y Watanabe, and
A Yamashita, and
Y Arai, and
O Hayaishi
June 1993,
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience,
H Tokumoto, and
Y Watanabe, and
A Yamashita, and
Y Arai, and
O Hayaishi
December 1986,
Journal of biochemistry,
H Tokumoto, and
Y Watanabe, and
A Yamashita, and
Y Arai, and
O Hayaishi
September 1980,
Brain research,
H Tokumoto, and
Y Watanabe, and
A Yamashita, and
Y Arai, and
O Hayaishi
January 1991,
Ukrainskii biokhimicheskii zhurnal (1978),
H Tokumoto, and
Y Watanabe, and
A Yamashita, and
Y Arai, and
O Hayaishi
November 1976,
Journal of neurochemistry,
H Tokumoto, and
Y Watanabe, and
A Yamashita, and
Y Arai, and
O Hayaishi
October 1983,
Proceedings of the National Academy of Sciences of the United States of America,
H Tokumoto, and
Y Watanabe, and
A Yamashita, and
Y Arai, and
O Hayaishi
January 1976,
Advances in prostaglandin and thromboxane research,
