BIOMAT Database Logo BIOMAT Database Logo

Cypermethrin inhibits interleukin-6-induced androgen receptor transactivation through signal transducer and activator of transcription 3. 2017

Ji-Long Zhou, and Zhen Ding, and Xing Ge, and Qiao-Mei Shi, and Heng-Xue Wang, and Gang Chen, and Meng-Xue Li, and Hui Wang, and Qiang Ju, and Qi Wang, and Jin-Peng Zhang, and Mei-Rong Zhang, and Li-Chun Xu
a School of Public Health , Xuzhou Medical University, Xuzhou , PR China.

The insecticide cypermethrin has been considered as an endocrine-disrupting chemicals (EDCs) with anti-androgenic activity by interfering with interleukin-6 (IL-6) - induced ligand-independent AR signaling. The purpose of this study was to clarify whether the signal transducer and activator of transcription 3 (STAT3) was involved in the antagonism effect of cypermethrin. In this study, the Western blot was to test the level of STAT3 phosphorylation and the mammalian two-hybrid assay was developed to assess the AR-STAT3 interaction. The date showed that IL-6 increased the phosphorylation level of STAT3 and enhanced the AR-STAT3 interaction. Cypermethrin did not affect the phosphorylation level of STAT3 induced by IL-6, while suppressed the AR-STAT3 interaction induced by IL-6 significantly at the concentration of 10-5 M (p < 0.05). The study indicates cypermethrin inhibits IL-6-induced AR signaling by suppressing the interaction between the AR and STAT3. We provide a novel mechanism of cypermethrin-mediated antagonism on IL-6-induced AR activation associated with STAT3.

UI MeSH Term Description Entries
D007306 Insecticides Pesticides designed to control insects that are harmful to man. The insects may be directly harmful, as those acting as disease vectors, or indirectly harmful, as destroyers of crops, food products, or textile fabrics. Insecticide
D010766 Phosphorylation The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety. Phosphorylations
D011722 Pyrethrins The active insecticidal constituent of CHRYSANTHEMUM CINERARIIFOLIUM flowers. Pyrethrin I is the pyretholone ester of chrysanthemummonocarboxylic acid and pyrethrin II is the pyretholone ester of chrysanthemumdicarboxylic acid monomethyl ester. Pyrethrin,Pyrethroid,Pyrethroids
D011944 Receptors, Androgen Proteins, generally found in the CYTOPLASM, that specifically bind ANDROGENS and mediate their cellular actions. The complex of the androgen and receptor migrates to the CELL NUCLEUS where it induces transcription of specific segments of DNA. Androgen Receptors,5 alpha-Dihydrotestosterone Receptor,Androgen Receptor,Dihydrotestosterone Receptors,Receptor, Testosterone,Receptors, Androgens,Receptors, Dihydrotestosterone,Receptors, Stanolone,Stanolone Receptor,Testosterone Receptor,5 alpha Dihydrotestosterone Receptor,Androgens Receptors,Receptor, 5 alpha-Dihydrotestosterone,Receptor, Androgen,Receptor, Stanolone,Stanolone Receptors,alpha-Dihydrotestosterone Receptor, 5
D002460 Cell Line Established cell cultures that have the potential to propagate indefinitely. Cell Lines,Line, Cell,Lines, Cell
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D015533 Transcriptional Activation Processes that stimulate the GENETIC TRANSCRIPTION of a gene or set of genes. Gene Activation,Genetic Induction,Transactivation,Induction, Genetic,Trans-Activation, Genetic,Transcription Activation,Activation, Gene,Activation, Transcription,Activation, Transcriptional,Genetic Trans-Activation,Trans Activation, Genetic
D015850 Interleukin-6 A cytokine that stimulates the growth and differentiation of B-LYMPHOCYTES and is also a growth factor for HYBRIDOMAS and plasmacytomas. It is produced by many different cells including T-LYMPHOCYTES; MONOCYTES; and FIBROBLASTS. Hepatocyte-Stimulating Factor,Hybridoma Growth Factor,IL-6,MGI-2,Myeloid Differentiation-Inducing Protein,Plasmacytoma Growth Factor,B Cell Stimulatory Factor-2,B-Cell Differentiation Factor,B-Cell Differentiation Factor-2,B-Cell Stimulatory Factor 2,B-Cell Stimulatory Factor-2,BSF-2,Differentiation Factor, B-Cell,Differentiation Factor-2, B-Cell,IFN-beta 2,IL6,Interferon beta-2,B Cell Differentiation Factor,B Cell Differentiation Factor 2,B Cell Stimulatory Factor 2,Differentiation Factor 2, B Cell,Differentiation Factor, B Cell,Differentiation-Inducing Protein, Myeloid,Growth Factor, Hybridoma,Growth Factor, Plasmacytoma,Hepatocyte Stimulating Factor,Interferon beta 2,Interleukin 6,Myeloid Differentiation Inducing Protein,beta-2, Interferon
D050796 STAT3 Transcription Factor A signal transducer and activator of transcription that mediates cellular responses to INTERLEUKIN-6 family members. STAT3 is constitutively activated in a variety of TUMORS and is a major downstream transducer for the CYTOKINE RECEPTOR GP130. APRF Transcription Factor,Acute-Phase Response Factor,IL6-Response Factor,LIF-Response Factor,STAT3 Protein,STAT3a Transcription Factor,STAT3b Transcription Factor,Signal Transducer and Activator of Transcription 3,Stat3alpha Transcription Factor,Stat3beta Transcription Factor,Acute Phase Response Factor,IL6 Response Factor,LIF Response Factor,Response Factor, Acute-Phase,Transcription Factor, APRF,Transcription Factor, STAT3,Transcription Factor, STAT3a,Transcription Factor, STAT3b,Transcription Factor, Stat3alpha,Transcription Factor, Stat3beta

Related Publications

Ji-Long Zhou, and Zhen Ding, and Xing Ge, and Qiao-Mei Shi, and Heng-Xue Wang, and Gang Chen, and Meng-Xue Li, and Hui Wang, and Qiang Ju, and Qi Wang, and Jin-Peng Zhang, and Mei-Rong Zhang, and Li-Chun Xu
Interleukin-6-induced epithelial-mesenchymal transition through signal transducer and activator of transcription 3 in human cervical carcinoma.
July 2014, International journal of oncology,
Ji-Long Zhou, and Zhen Ding, and Xing Ge, and Qiao-Mei Shi, and Heng-Xue Wang, and Gang Chen, and Meng-Xue Li, and Hui Wang, and Qiang Ju, and Qi Wang, and Jin-Peng Zhang, and Mei-Rong Zhang, and Li-Chun Xu
Interleukin-6 induction of protein s is regulated through signal transducer and activator of transcription 3.
September 2006, Arteriosclerosis, thrombosis, and vascular biology,
Ji-Long Zhou, and Zhen Ding, and Xing Ge, and Qiao-Mei Shi, and Heng-Xue Wang, and Gang Chen, and Meng-Xue Li, and Hui Wang, and Qiang Ju, and Qi Wang, and Jin-Peng Zhang, and Mei-Rong Zhang, and Li-Chun Xu
Interplay of Epidermal Growth Factor Receptor and Signal Transducer and Activator of Transcription 3 in Prostate Cancer: Beyond Androgen Receptor Transactivation.
July 2021, Cancers,
Ji-Long Zhou, and Zhen Ding, and Xing Ge, and Qiao-Mei Shi, and Heng-Xue Wang, and Gang Chen, and Meng-Xue Li, and Hui Wang, and Qiang Ju, and Qi Wang, and Jin-Peng Zhang, and Mei-Rong Zhang, and Li-Chun Xu
Interleukin 6 activates androgen receptor-mediated gene expression through a signal transducer and activator of transcription 3-dependent pathway in LNCaP prostate cancer cells.
April 2000, Cancer research,
Ji-Long Zhou, and Zhen Ding, and Xing Ge, and Qiao-Mei Shi, and Heng-Xue Wang, and Gang Chen, and Meng-Xue Li, and Hui Wang, and Qiang Ju, and Qi Wang, and Jin-Peng Zhang, and Mei-Rong Zhang, and Li-Chun Xu
Sulforaphane inhibits constitutive and interleukin-6-induced activation of signal transducer and activator of transcription 3 in prostate cancer cells.
April 2010, Cancer prevention research (Philadelphia, Pa.),
Ji-Long Zhou, and Zhen Ding, and Xing Ge, and Qiao-Mei Shi, and Heng-Xue Wang, and Gang Chen, and Meng-Xue Li, and Hui Wang, and Qiang Ju, and Qi Wang, and Jin-Peng Zhang, and Mei-Rong Zhang, and Li-Chun Xu
Interleukin-6 receptor-mediated activation of signal transducer and activator of transcription-3 (STAT3) promotes choroidal neovascularization.
June 2007, The American journal of pathology,
Ji-Long Zhou, and Zhen Ding, and Xing Ge, and Qiao-Mei Shi, and Heng-Xue Wang, and Gang Chen, and Meng-Xue Li, and Hui Wang, and Qiang Ju, and Qi Wang, and Jin-Peng Zhang, and Mei-Rong Zhang, and Li-Chun Xu
Rapamycin inhibits cholangiocyte regeneration by blocking interleukin-6-induced activation of signal transducer and activator of transcription 3 after liver transplantation.
February 2010, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society,
Ji-Long Zhou, and Zhen Ding, and Xing Ge, and Qiao-Mei Shi, and Heng-Xue Wang, and Gang Chen, and Meng-Xue Li, and Hui Wang, and Qiang Ju, and Qi Wang, and Jin-Peng Zhang, and Mei-Rong Zhang, and Li-Chun Xu
Interleukin-6-induced activation of signal transducer and activator of transcription-3 in ruptured rotator cuff tendon.
January 2006, The Journal of international medical research,
Ji-Long Zhou, and Zhen Ding, and Xing Ge, and Qiao-Mei Shi, and Heng-Xue Wang, and Gang Chen, and Meng-Xue Li, and Hui Wang, and Qiang Ju, and Qi Wang, and Jin-Peng Zhang, and Mei-Rong Zhang, and Li-Chun Xu
Butein effects in colitis and interleukin-6/signal transducer and activator of transcription 3 expression.
January 2015, World journal of gastroenterology,
Ji-Long Zhou, and Zhen Ding, and Xing Ge, and Qiao-Mei Shi, and Heng-Xue Wang, and Gang Chen, and Meng-Xue Li, and Hui Wang, and Qiang Ju, and Qi Wang, and Jin-Peng Zhang, and Mei-Rong Zhang, and Li-Chun Xu
Brazilian propolis inhibits the differentiation of Th17 cells by inhibition of interleukin-6-induced phosphorylation of signal transducer and activator of transcription 3.
October 2012, Immunopharmacology and immunotoxicology,
Copied contents to your clipboard!