-transparent.png){kind=logo}
The remarkable antiulcer and antisecretory activity of some previously described 4,5,6,7-tetrahydroimidazo[4,5-c]pyridine derivatives prompted us to further investigate related bicyclic systems. Accordingly, a series of 5-amino- and 5-aminomethyl-4,5,6,7-tetrahydrobenzimidazoles, regiospecifically alkylated in position 1, were synthesized and tested. Only a few 1-ethyl-5-amino derivatives displayed a reasonable antiulcer activity in comparison with our former class of compounds.
Related Publications
U Scarponi, and
R Cimaschi, and
L Rusconi, and
F Santangelo, and
G Arcari, and
R Castello, and
D Toti, and
R de Castiglione
January 1988,
Il Farmaco; edizione scientifica,
U Scarponi, and
R Cimaschi, and
L Rusconi, and
F Santangelo, and
G Arcari, and
R Castello, and
D Toti, and
R de Castiglione
August 1997,
Drug design and discovery,
U Scarponi, and
R Cimaschi, and
L Rusconi, and
F Santangelo, and
G Arcari, and
R Castello, and
D Toti, and
R de Castiglione
February 1976,
The Journal of pharmacy and pharmacology,
U Scarponi, and
R Cimaschi, and
L Rusconi, and
F Santangelo, and
G Arcari, and
R Castello, and
D Toti, and
R de Castiglione
June 2013,
World journal of gastroenterology,
U Scarponi, and
R Cimaschi, and
L Rusconi, and
F Santangelo, and
G Arcari, and
R Castello, and
D Toti, and
R de Castiglione
December 1981,
Chemical & pharmaceutical bulletin,
U Scarponi, and
R Cimaschi, and
L Rusconi, and
F Santangelo, and
G Arcari, and
R Castello, and
D Toti, and
R de Castiglione
October 1976,
The Journal of pharmacy and pharmacology,
U Scarponi, and
R Cimaschi, and
L Rusconi, and
F Santangelo, and
G Arcari, and
R Castello, and
D Toti, and
R de Castiglione
January 2003,
Research communications in molecular pathology and pharmacology,
U Scarponi, and
R Cimaschi, and
L Rusconi, and
F Santangelo, and
G Arcari, and
R Castello, and
D Toti, and
R de Castiglione
January 1989,
Farmaco (Societa chimica italiana : 1989),
U Scarponi, and
R Cimaschi, and
L Rusconi, and
F Santangelo, and
G Arcari, and
R Castello, and
D Toti, and
R de Castiglione
January 1974,
Advances in drug research,
U Scarponi, and
R Cimaschi, and
L Rusconi, and
F Santangelo, and
G Arcari, and
R Castello, and
D Toti, and
R de Castiglione
January 1978,
Digestion,
