-transparent.png){kind=logo}
In rat substantia nigra a biphasic disappearance curve of dopamine (DA) was seen after tyrosine hydroxylase inhibition by alpha-methyl-p-tyrosine (alpha-MT): the initial phase had a fast turnover and a half life of 0.5 h and the later phase had an extremely slow turnover. In contrast to the effects in striatum, neither haloperidol nor apomorphine influenced alpha-MT-induced DA disappearance in the substantia nigra. Furthermore, inhibition of impulse flow by gamma-butyrolactone prevented DA disappearance in striatum but not in the substantia nigra. Measurements of DA and 3-methoxytyramine following treatment with inhibitors of monoamine oxidase (pargyline) and catechol-O-methyl transferase (tropolone) indicated that O-methylation is a more important metabolic pathway in the substantia nigra than in the striatum. The data are interpreted to indicate that the release and metabolism of DA in the substantia nigra are largely beyond the control of nerve impulses and DA receptors. It is suggested that such an arrangement forms an important feature of autoreceptor-mediated feedback control of DA nerve cell activity.
H Nissbrandt, and
E Pileblad, and
A Carlsson
March 1976,
Nature,
H Nissbrandt, and
E Pileblad, and
A Carlsson
March 1976,
Nature,
H Nissbrandt, and
E Pileblad, and
A Carlsson
April 2002,
Biochemical pharmacology,
H Nissbrandt, and
E Pileblad, and
A Carlsson
January 1978,
Advances in biochemical psychopharmacology,
H Nissbrandt, and
E Pileblad, and
A Carlsson
May 2002,
Neuroscience letters,
H Nissbrandt, and
E Pileblad, and
A Carlsson
January 1978,
Naunyn-Schmiedeberg's archives of pharmacology,
H Nissbrandt, and
E Pileblad, and
A Carlsson
February 1981,
Nature,
H Nissbrandt, and
E Pileblad, and
A Carlsson
January 1979,
Applied neurophysiology,
H Nissbrandt, and
E Pileblad, and
A Carlsson
January 1999,
Folia histochemica et cytobiologica,
H Nissbrandt, and
E Pileblad, and
A Carlsson
August 1991,
Brain research,
