Biomaterial Database

Glutamine metabolism in the avian host bearing transplantable hepatomatous growth induced by MC-29 virus. 1986

T Matsuno, and T Satoh

The concentrations of free amino acids have been determined in the sera of chickens bearing transplanted hepatomatous growths induced by MC-29 virus and their pair-fed controls. Decreases in serine and glutamine concentrations were observed when the tumors developed; the latter being more prominent. Glutamine synthetase activities in the liver and thigh muscle were increased as the tumors grew larger. Elevation of serum uric acid was observed in the tumor-bearing chickens. Liver glutamine-PRPP-amidotransferase activity was not affected by the tumor growth. In the hepatomatous tissue, activity of glutamine synthetase was low and below one-tenth of that in liver. Glutaminase activities, phosphate-dependent and phosphate-independent, were increased. Glutamine-PRPP-amidotransferase activity was about half compared to that in liver.

UI	MeSH Term	Description	Entries
D008099	Liver	A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.	Livers
D008114	Liver Neoplasms, Experimental	Experimentally induced tumors of the LIVER.	Hepatoma, Experimental,Hepatoma, Morris,Hepatoma, Novikoff,Experimental Hepatoma,Experimental Hepatomas,Experimental Liver Neoplasms,Hepatomas, Experimental,Neoplasms, Experimental Liver,Experimental Liver Neoplasm,Liver Neoplasm, Experimental,Morris Hepatoma,Novikoff Hepatoma
D009368	Neoplasm Transplantation	Experimental transplantation of neoplasms in laboratory animals for research purposes.	Transplantation, Neoplasm,Neoplasm Transplantations,Transplantations, Neoplasm
D002645	Chickens	Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.	Gallus gallus,Gallus domesticus,Gallus gallus domesticus,Chicken
D005972	Glutaminase		Phosphate-Activated Glutaminase,Glutaminase, Phosphate-Activated,Phosphate Activated Glutaminase
D005973	Glutamine	A non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. It is synthesized from GLUTAMIC ACID and AMMONIA. It is the principal carrier of NITROGEN in the body and is an important energy source for many cells.	D-Glutamine,L-Glutamine,D Glutamine,L Glutamine
D005974	Glutamate-Ammonia Ligase	An enzyme that catalyzes the conversion of ATP, L-glutamate, and NH3 to ADP, orthophosphate, and L-glutamine. It also acts more slowly on 4-methylene-L-glutamate. (From Enzyme Nomenclature, 1992) EC 6.3.1.2.	Glutamine Synthetase,Glutamate Ammonia Ligase (ADP),Glutamate Ammonia Ligase,Ligase, Glutamate-Ammonia,Synthetase, Glutamine
D000582	Amidophosphoribosyltransferase	An enzyme, involved in the early steps of purine nucleotide biosynthesis, that catalyzes the formation of 5-phosphoribosylamine from glutamine and phosphoribosylpyrophosphate. EC 2.4.2.14.	Glutamine Phosphoribosyl Pyrophosphate Amidotransferase,Phosphoribosyl Pyrophosphate Amidotransferase,Glutamine-Amidophosphoribosyltransferase,Phosphoribosyldiphosphate 5-Amidotransferase,5-Amidotransferase, Phosphoribosyldiphosphate,Amidotransferase, Phosphoribosyl Pyrophosphate,Glutamine Amidophosphoribosyltransferase,Phosphoribosyldiphosphate 5 Amidotransferase,Pyrophosphate Amidotransferase, Phosphoribosyl
D000596	Amino Acids	Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.	Amino Acid,Acid, Amino,Acids, Amino
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia