-transparent.png){kind=logo}
Highly efficient chemoenzymatic synthesis and facile purification of α-Gal pentasaccharyl ceramide Galα3nLc4βCer. 2017
Department of Chemistry, University of California, One shields Avenue, Davis, CA 95616, USA. xiichen@ucdavis.edu.
A highly efficient chemoenzymatic method for synthesizing glycosphingolipids using α-Gal pentasaccharyl ceramide as an example is reported here. Enzymatic extension of the chemically synthesized lactosyl sphingosine using efficient sequential one-pot multienzyme (OPME) reactions allowed glycosylation to be carried out in aqueous solutions. Facile C18 cartridge-based quick (<30 minutes) purification protocols were established using minimal amounts of green solvents (CH3CN and H2O). Simple acylation in the last step led to the formation of the target glycosyl ceramide in 4 steps with an overall yield of 57%.
| UI | MeSH Term | Description | Entries |
|---|
Related Publications
Abhishek Santra, and
Yanhong Li, and
Hai Yu, and
Teri J Slack, and
Peng George Wang, and
Xi Chen
March 2021,
Current protocols,
Abhishek Santra, and
Yanhong Li, and
Hai Yu, and
Teri J Slack, and
Peng George Wang, and
Xi Chen
July 2006,
Organic letters,
Abhishek Santra, and
Yanhong Li, and
Hai Yu, and
Teri J Slack, and
Peng George Wang, and
Xi Chen
May 2019,
Bioorganic & medicinal chemistry letters,
Abhishek Santra, and
Yanhong Li, and
Hai Yu, and
Teri J Slack, and
Peng George Wang, and
Xi Chen
October 2010,
Chemical communications (Cambridge, England),
Abhishek Santra, and
Yanhong Li, and
Hai Yu, and
Teri J Slack, and
Peng George Wang, and
Xi Chen
July 2018,
Angewandte Chemie (International ed. in English),
Abhishek Santra, and
Yanhong Li, and
Hai Yu, and
Teri J Slack, and
Peng George Wang, and
Xi Chen
May 2015,
Organic & biomolecular chemistry,
Abhishek Santra, and
Yanhong Li, and
Hai Yu, and
Teri J Slack, and
Peng George Wang, and
Xi Chen
February 2005,
Bioorganic & medicinal chemistry letters,
Abhishek Santra, and
Yanhong Li, and
Hai Yu, and
Teri J Slack, and
Peng George Wang, and
Xi Chen
May 2008,
The Journal of organic chemistry,
Abhishek Santra, and
Yanhong Li, and
Hai Yu, and
Teri J Slack, and
Peng George Wang, and
Xi Chen
July 2010,
Nucleosides, nucleotides & nucleic acids,
Abhishek Santra, and
Yanhong Li, and
Hai Yu, and
Teri J Slack, and
Peng George Wang, and
Xi Chen
January 2019,
Beilstein journal of organic chemistry,
