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The direct inotropic actions of ethmozine and of its diethylamine analog, ethacizin, were studied in the presence of muscarinic and beta-adrenoreceptor blockade in 12 ferret right ventricular papillary muscles. In each muscle ethmozine caused a small but consistent and significant (p less than 0.05) increase in contractile performance, whereas ethacizin significantly (p less than 0.05) diminished contractility. Although both phenothiazines are fast channel blockers, it appears that the net positive inotropic action of ethmozine is due to its stimulatory effect on the slow inward current and that the negative inotropic action of ethacizin is largely due to its recently demonstrated decreases of the slow inward current.
F Urthaler, and
L V Rosenshtraukh, and
A A Walker, and
G R Hageman
April 1986,
Kardiologiia,
F Urthaler, and
L V Rosenshtraukh, and
A A Walker, and
G R Hageman
January 1985,
Biulleten' Vsesoiuznogo kardiologicheskogo nauchnogo tsentra AMN SSSR,
F Urthaler, and
L V Rosenshtraukh, and
A A Walker, and
G R Hageman
March 1988,
Biulleten' eksperimental'noi biologii i meditsiny,
F Urthaler, and
L V Rosenshtraukh, and
A A Walker, and
G R Hageman
October 1982,
Biulleten' eksperimental'noi biologii i meditsiny,
F Urthaler, and
L V Rosenshtraukh, and
A A Walker, and
G R Hageman
October 1982,
Biulleten' eksperimental'noi biologii i meditsiny,
F Urthaler, and
L V Rosenshtraukh, and
A A Walker, and
G R Hageman
January 1983,
Biulleten' Vsesoiuznogo kardiologicheskogo nauchnogo tsentra AMN SSSR,
F Urthaler, and
L V Rosenshtraukh, and
A A Walker, and
G R Hageman
March 1985,
Kardiologiia,
F Urthaler, and
L V Rosenshtraukh, and
A A Walker, and
G R Hageman
January 1983,
Terapevticheskii arkhiv,
F Urthaler, and
L V Rosenshtraukh, and
A A Walker, and
G R Hageman
October 1981,
Kardiologiia,
F Urthaler, and
L V Rosenshtraukh, and
A A Walker, and
G R Hageman
March 1979,
Biulleten' eksperimental'noi biologii i meditsiny,
