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As a first step toward assessing the status of brain neuropeptide systems that may be involved in Alzheimer's disease (AD), the cerebrospinal fluid (CSF) concentrations of the neuropeptides arginine vasopressin, somatostatin, oxytocin, and beta-endorphin were measured in patients with AD, normal elderly subjects, and normal young subjects. The plasma arginine vasopressin level was also measured in the three groups. The CSF arginine vasopressin level was significantly lower in patients with AD than in either elderly or young normal subjects, but oxytocin and beta-endorphin levels did not differ between groups. The CSF osmolarity also did not differ between groups. The plasma arginine vasopressin level did not significantly differ between groups, but high plasma arginine vasopressin values were absent in the patients with AD. The CSF somatostatin level was significantly lower in patients with AD than in normal elderly persons, but it did not differ in young normal subjects. These results suggest that central vasopressinergic activity may be decreased in AD and confirm reports of low CSF somatostatin levels in AD.
M A Raskind, and
E R Peskind, and
T H Lampe, and
S C Risse, and
G J Taborsky, and
D Dorsa
February 1987,
Journal of the neurological sciences,
M A Raskind, and
E R Peskind, and
T H Lampe, and
S C Risse, and
G J Taborsky, and
D Dorsa
February 1990,
Acta endocrinologica,
M A Raskind, and
E R Peskind, and
T H Lampe, and
S C Risse, and
G J Taborsky, and
D Dorsa
July 1978,
Lancet (London, England),
M A Raskind, and
E R Peskind, and
T H Lampe, and
S C Risse, and
G J Taborsky, and
D Dorsa
January 1987,
Materia medica Polona. Polish journal of medicine and pharmacy,
M A Raskind, and
E R Peskind, and
T H Lampe, and
S C Risse, and
G J Taborsky, and
D Dorsa
October 1987,
Journal of neurology, neurosurgery, and psychiatry,
M A Raskind, and
E R Peskind, and
T H Lampe, and
S C Risse, and
G J Taborsky, and
D Dorsa
September 1986,
Biological psychiatry,
M A Raskind, and
E R Peskind, and
T H Lampe, and
S C Risse, and
G J Taborsky, and
D Dorsa
February 1980,
The Journal of clinical endocrinology and metabolism,
M A Raskind, and
E R Peskind, and
T H Lampe, and
S C Risse, and
G J Taborsky, and
D Dorsa
December 1982,
Australian paediatric journal,
M A Raskind, and
E R Peskind, and
T H Lampe, and
S C Risse, and
G J Taborsky, and
D Dorsa
May 1991,
Developmental medicine and child neurology,
M A Raskind, and
E R Peskind, and
T H Lampe, and
S C Risse, and
G J Taborsky, and
D Dorsa
August 1982,
The Journal of clinical endocrinology and metabolism,
