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Hemodynamic effects of labetalol, an alpha- and beta-adrenoceptor blocking drug, were investigated in the conscious dog and in the anesthetized open-chest dog. In the conscious dog, intravenous injection of labetalol, in a dose of 0.5 mg/kg, decreased the total peripheral resistance by approximately 20% (P less than 0.01) in association with falls in blood pressure and heart rate. The total peripheral resistance of the anesthetized open-chest dog was not affected by labetalol in the presence of the same extent of blood pressure fall as results of the conscious dog. In contrast, agents which have beta-adrenoceptor blocking effect alone provided substantial elevation of the total peripheral resistance in the anesthetized dog. These results indicate that the different responses of the resistance to labetalol probably result from the vascular alpha-adrenoceptor blocking action, and also show that in the conscious state alpha-adrenoceptor blocking action of labetalol is enhanced in comparison with the effect in the anesthetized open-chest dog.
D Saito, and
Y Abe, and
H Tani, and
S Kusachi, and
K Takeda, and
T Hyodo, and
S Haraoka, and
H Nagashima
December 1996,
Critical care medicine,
D Saito, and
Y Abe, and
H Tani, and
S Kusachi, and
K Takeda, and
T Hyodo, and
S Haraoka, and
H Nagashima
May 1989,
Zhongguo yao li xue bao = Acta pharmacologica Sinica,
D Saito, and
Y Abe, and
H Tani, and
S Kusachi, and
K Takeda, and
T Hyodo, and
S Haraoka, and
H Nagashima
March 1984,
American heart journal,
D Saito, and
Y Abe, and
H Tani, and
S Kusachi, and
K Takeda, and
T Hyodo, and
S Haraoka, and
H Nagashima
September 1981,
Japanese heart journal,
D Saito, and
Y Abe, and
H Tani, and
S Kusachi, and
K Takeda, and
T Hyodo, and
S Haraoka, and
H Nagashima
February 1990,
European journal of pharmacology,
D Saito, and
Y Abe, and
H Tani, and
S Kusachi, and
K Takeda, and
T Hyodo, and
S Haraoka, and
H Nagashima
June 1989,
Hypertension (Dallas, Tex. : 1979),
D Saito, and
Y Abe, and
H Tani, and
S Kusachi, and
K Takeda, and
T Hyodo, and
S Haraoka, and
H Nagashima
December 1976,
The American journal of digestive diseases,
D Saito, and
Y Abe, and
H Tani, and
S Kusachi, and
K Takeda, and
T Hyodo, and
S Haraoka, and
H Nagashima
September 1989,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
D Saito, and
Y Abe, and
H Tani, and
S Kusachi, and
K Takeda, and
T Hyodo, and
S Haraoka, and
H Nagashima
May 1994,
Critical care medicine,
D Saito, and
Y Abe, and
H Tani, and
S Kusachi, and
K Takeda, and
T Hyodo, and
S Haraoka, and
H Nagashima
January 1992,
Archives internationales de pharmacodynamie et de therapie,
