Biomaterial Database

[Activity of almitrine bismesylate on pulmonary hemodynamics and on the liberation of prostanoids in the lymph nodes in sheep]. 1985

D Douguet, and F Dray, and J M Chollet, and M Zelter

Almitrine Bismesylate (0.25 mg X kg-1) was perfused for 10 minutes into the pulmonary artery of 4 sheep (40 kg) which were anaesthetized, paralysed and ventilated with 50% oxygen in air and prepared according to Staub et al (J. Surg. Res. 19:315, 1975). The preparation was followed for 2 hours baseline and for four hours after perfusion and comparisons made using analysis of variance. We noted a transitory phase marked by a peak of pulmonary vascular resistance (PVR) at 25 +/- 15 minutes due to a rise in mean pulmonary artery pressure PAP from 14 +/- 2 to 23 +/- 5 cm H2O. PO2 fell from 220 +/- 40 to 180 +/- 25 Torr. A stable haemodynamic state was attained after 90 minutes. PAP was slightly above control and PaO2 significantly elevated (230 +/- 30 Torr P less than 0.05). Left atrial pressure, PCO2, pH, and lung lymph flow did not change. The mild stable vasoconstriction associated to a rise in PaO2 at constant ventilation and high PaO2 does not suggest a straightforward role for chemoreceptors. It is compatible with redistribution of VA/Q ratios by local mediators. Lung lymph was assayed for prostanoids using radio immunological methods. A significant rise in 6 keto PGF1 alpha immunoreactivity was found posterior to the haemodynamic peak. HPLC is required to quantify further this rise.

UI	MeSH Term	Description	Entries
D008196	Lymph	The interstitial fluid that is in the LYMPHATIC SYSTEM.	Lymphs
D010879	Piperazines	Compounds that are derived from PIPERAZINE.
D011652	Pulmonary Circulation	The circulation of the BLOOD through the LUNGS.	Pulmonary Blood Flow,Respiratory Circulation,Circulation, Pulmonary,Circulation, Respiratory,Blood Flow, Pulmonary,Flow, Pulmonary Blood,Pulmonary Blood Flows
D011659	Pulmonary Gas Exchange	The exchange of OXYGEN and CARBON DIOXIDE between alveolar air and pulmonary capillary blood that occurs across the BLOOD-AIR BARRIER.	Exchange, Pulmonary Gas,Gas Exchange, Pulmonary
D000697	Central Nervous System Stimulants	A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here.	Analeptic,Analeptic Agent,Analeptic Drug,Analeptics,CNS Stimulant,CNS Stimulants,Central Nervous System Stimulant,Central Stimulant,Analeptic Agents,Analeptic Drugs,Central Stimulants,Agent, Analeptic,Agents, Analeptic,Drug, Analeptic,Drugs, Analeptic,Stimulant, CNS,Stimulant, Central,Stimulants, CNS,Stimulants, Central
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012756	Sheep	Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.	Ovis,Sheep, Dall,Dall Sheep,Ovis dalli
D014661	Vasoconstriction	The physiological narrowing of BLOOD VESSELS by contraction of the VASCULAR SMOOTH MUSCLE.	Vasoconstrictions
D015121	6-Ketoprostaglandin F1 alpha	The physiologically active and stable hydrolysis product of EPOPROSTENOL. Found in nearly all mammalian tissue.	6-Keto-PGF1 alpha,6-Oxo-PGF1 alpha,6-Oxoprostaglandin F1 alpha,6 Ketoprostaglandin F1 alpha,6 Keto PGF1 alpha,6 Oxo PGF1 alpha,6 Oxoprostaglandin F1 alpha,F1 alpha, 6-Ketoprostaglandin,F1 alpha, 6-Oxoprostaglandin,alpha, 6-Keto-PGF1,alpha, 6-Ketoprostaglandin F1,alpha, 6-Oxo-PGF1,alpha, 6-Oxoprostaglandin F1
D015765	Almitrine	A respiratory stimulant that enhances respiration by acting as an agonist of peripheral chemoreceptors located on the carotid bodies. The drug increases arterial oxygen tension while decreasing arterial carbon dioxide tension in patients with chronic obstructive pulmonary disease. It may also prove useful in the treatment of nocturnal oxygen desaturation without impairing the quality of sleep.	Almitrine Bismesylate,Almitrine Bis(methanesulfonate),Almitrine Dimesylate,Almitrine Monomesylate,Vectarion,Monomesylate, Almitrine