BIOMAT Database Logo BIOMAT Database Logo

Endothelial Notch signalling limits angiogenesis via control of artery formation. 2017

Sana S Hasan, and Roman Tsaryk, and Martin Lange, and Laura Wisniewski, and John C Moore, and Nathan D Lawson, and Karolina Wojciechowska, and Hans Schnittler, and Arndt F Siekmann
Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, D-48149 Münster, Germany.

Angiogenic sprouting needs to be tightly controlled. It has been suggested that the Notch ligand dll4 expressed in leading tip cells restricts angiogenesis by activating Notch signalling in trailing stalk cells. Here, we show using live imaging in zebrafish that activation of Notch signalling is rather required in tip cells. Notch activation initially triggers expression of the chemokine receptor cxcr4a. This allows for proper tip cell migration and connection to the pre-existing arterial circulation, ultimately establishing functional arterial-venous blood flow patterns. Subsequently, Notch signalling reduces cxcr4a expression, thereby preventing excessive blood vessel growth. Finally, we find that Notch signalling is dispensable for limiting blood vessel growth during venous plexus formation that does not generate arteries. Together, these findings link the role of Notch signalling in limiting angiogenesis to its role during artery formation and provide a framework for our understanding of the mechanisms underlying blood vessel network expansion and maturation.

UI MeSH Term Description Entries
D008565 Membrane Proteins Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors. Cell Membrane Protein,Cell Membrane Proteins,Cell Surface Protein,Cell Surface Proteins,Integral Membrane Proteins,Membrane-Associated Protein,Surface Protein,Surface Proteins,Integral Membrane Protein,Membrane Protein,Membrane-Associated Proteins,Membrane Associated Protein,Membrane Associated Proteins,Membrane Protein, Cell,Membrane Protein, Integral,Membrane Proteins, Integral,Protein, Cell Membrane,Protein, Cell Surface,Protein, Integral Membrane,Protein, Membrane,Protein, Membrane-Associated,Protein, Surface,Proteins, Cell Membrane,Proteins, Cell Surface,Proteins, Integral Membrane,Proteins, Membrane,Proteins, Membrane-Associated,Proteins, Surface,Surface Protein, Cell
D008856 Microscopy, Fluorescence Microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light. Immunofluorescence microscopy utilizes antibodies that are labeled with fluorescent dye. Fluorescence Microscopy,Immunofluorescence Microscopy,Microscopy, Immunofluorescence,Fluorescence Microscopies,Immunofluorescence Microscopies,Microscopies, Fluorescence,Microscopies, Immunofluorescence
D009419 Nerve Tissue Proteins Proteins, Nerve Tissue,Tissue Proteins, Nerve
D010641 Phenotype The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment. Phenotypes
D002465 Cell Movement The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell. Cell Migration,Locomotion, Cell,Migration, Cell,Motility, Cell,Movement, Cell,Cell Locomotion,Cell Motility,Cell Movements,Movements, Cell
D002478 Cells, Cultured Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others. Cultured Cells,Cell, Cultured,Cultured Cell
D005838 Genotype The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS. Genogroup,Genogroups,Genotypes
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001158 Arteries The vessels carrying blood away from the heart. Artery

Related Publications

Sana S Hasan, and Roman Tsaryk, and Martin Lange, and Laura Wisniewski, and John C Moore, and Nathan D Lawson, and Karolina Wojciechowska, and Hans Schnittler, and Arndt F Siekmann
Dll4 and Notch signalling couples sprouting angiogenesis and artery formation.
August 2017, Nature cell biology,
Sana S Hasan, and Roman Tsaryk, and Martin Lange, and Laura Wisniewski, and John C Moore, and Nathan D Lawson, and Karolina Wojciechowska, and Hans Schnittler, and Arndt F Siekmann
Endothelial basement membrane limits tip cell formation by inducing Dll4/Notch signalling in vivo.
October 2011, EMBO reports,
Sana S Hasan, and Roman Tsaryk, and Martin Lange, and Laura Wisniewski, and John C Moore, and Nathan D Lawson, and Karolina Wojciechowska, and Hans Schnittler, and Arndt F Siekmann
Endothelial signalling by the Notch ligand Delta-like 4 restricts angiogenesis.
March 2007, Development (Cambridge, England),
Sana S Hasan, and Roman Tsaryk, and Martin Lange, and Laura Wisniewski, and John C Moore, and Nathan D Lawson, and Karolina Wojciechowska, and Hans Schnittler, and Arndt F Siekmann
Notch signalling in ischaemia-induced angiogenesis.
December 2009, Biochemical Society transactions,
Sana S Hasan, and Roman Tsaryk, and Martin Lange, and Laura Wisniewski, and John C Moore, and Nathan D Lawson, and Karolina Wojciechowska, and Hans Schnittler, and Arndt F Siekmann
NOTCH signalling in ovarian cancer angiogenesis.
December 2020, Annals of translational medicine,
Sana S Hasan, and Roman Tsaryk, and Martin Lange, and Laura Wisniewski, and John C Moore, and Nathan D Lawson, and Karolina Wojciechowska, and Hans Schnittler, and Arndt F Siekmann
Notch signalling and the regulation of angiogenesis.
January 2007, Cell adhesion & migration,
Sana S Hasan, and Roman Tsaryk, and Martin Lange, and Laura Wisniewski, and John C Moore, and Nathan D Lawson, and Karolina Wojciechowska, and Hans Schnittler, and Arndt F Siekmann
A new model of Notch signalling: Control of Notch receptor cis-inhibition via Notch ligand dimers.
January 2023, PLoS computational biology,
Sana S Hasan, and Roman Tsaryk, and Martin Lange, and Laura Wisniewski, and John C Moore, and Nathan D Lawson, and Karolina Wojciechowska, and Hans Schnittler, and Arndt F Siekmann
Dishevelled limits Notch signalling through inhibition of CSL.
December 2012, Development (Cambridge, England),
Sana S Hasan, and Roman Tsaryk, and Martin Lange, and Laura Wisniewski, and John C Moore, and Nathan D Lawson, and Karolina Wojciechowska, and Hans Schnittler, and Arndt F Siekmann
The role of Notch signalling in ovarian angiogenesis.
March 2017, Journal of ovarian research,
Sana S Hasan, and Roman Tsaryk, and Martin Lange, and Laura Wisniewski, and John C Moore, and Nathan D Lawson, and Karolina Wojciechowska, and Hans Schnittler, and Arndt F Siekmann
Non-canonical NOTCH3 signalling limits tumour angiogenesis.
July 2017, Nature communications,
Copied contents to your clipboard!