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A simple and sensitive radioimmunoassay was developed for measurement of immunoreactive atrial natriuretic factor (IR-ANF) in rat and human plasma and in rat atria. The two atria contain about 20 micrograms ANF per rat. The right atrium contained 2.5 times more ANF than did the left. Ether anesthesia and morphine markedly increased IR-ANF in rat plasma. The concentration of IR-ANF in plasma of clinically normal human subjects was 65.3 +/- 2.5 pg/ml. Paroxysmal tachycardia and rapid atrial pacing significantly increased IR-ANF in human plasma. Two- to seven-fold higher concentrations were found in coronary sinus blood than in the peripheral circulation. In the plasma of rats and humans, circulating ANF is probably a small-molecular-weight peptide. ANF acts on the adrenal and the pituitary. ANF inhibits aldosterone secretion from rat zona glomerulosa and steroid secretion by bovine adrenal zona glomerulosa and fasciculata. ANF stimulated the basal secretion of arginine vasopressin (AVP) in vitro and inhibited KCl-stimulated release of AVP.
J Gutkowska, and
K Horký, and
E L Schiffrin, and
G Thibault, and
R Garcia, and
G A De Léan, and
P Hamet, and
J Tremblay, and
M B Anand-Srivastava, and
P Januszewicz
January 1987,
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology,
J Gutkowska, and
K Horký, and
E L Schiffrin, and
G Thibault, and
R Garcia, and
G A De Léan, and
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M B Anand-Srivastava, and
P Januszewicz
February 1989,
Clinical biochemistry,
J Gutkowska, and
K Horký, and
E L Schiffrin, and
G Thibault, and
R Garcia, and
G A De Léan, and
P Hamet, and
J Tremblay, and
M B Anand-Srivastava, and
P Januszewicz
July 1984,
Biochemical and biophysical research communications,
J Gutkowska, and
K Horký, and
E L Schiffrin, and
G Thibault, and
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G A De Léan, and
P Hamet, and
J Tremblay, and
M B Anand-Srivastava, and
P Januszewicz
December 2004,
General and comparative endocrinology,
J Gutkowska, and
K Horký, and
E L Schiffrin, and
G Thibault, and
R Garcia, and
G A De Léan, and
P Hamet, and
J Tremblay, and
M B Anand-Srivastava, and
P Januszewicz
March 1987,
Endocrinology and metabolism clinics of North America,
J Gutkowska, and
K Horký, and
E L Schiffrin, and
G Thibault, and
R Garcia, and
G A De Léan, and
P Hamet, and
J Tremblay, and
M B Anand-Srivastava, and
P Januszewicz
February 1986,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
J Gutkowska, and
K Horký, and
E L Schiffrin, and
G Thibault, and
R Garcia, and
G A De Léan, and
P Hamet, and
J Tremblay, and
M B Anand-Srivastava, and
P Januszewicz
July 1985,
Biochemical and biophysical research communications,
J Gutkowska, and
K Horký, and
E L Schiffrin, and
G Thibault, and
R Garcia, and
G A De Léan, and
P Hamet, and
J Tremblay, and
M B Anand-Srivastava, and
P Januszewicz
December 1993,
Journal of hypertension. Supplement : official journal of the International Society of Hypertension,
J Gutkowska, and
K Horký, and
E L Schiffrin, and
G Thibault, and
R Garcia, and
G A De Léan, and
P Hamet, and
J Tremblay, and
M B Anand-Srivastava, and
P Januszewicz
November 1987,
Nihon rinsho. Japanese journal of clinical medicine,
J Gutkowska, and
K Horký, and
E L Schiffrin, and
G Thibault, and
R Garcia, and
G A De Léan, and
P Hamet, and
J Tremblay, and
M B Anand-Srivastava, and
P Januszewicz
July 1992,
The Clinical investigator,
