Biomaterial Database

Pathology Imagebase-a reference image database for standardization of pathology. 2017

Lars Egevad, and John Cheville, and Andrew J Evans, and Jonas Hörnblad, and James G Kench, and Glen Kristiansen, and Katia R M Leite, and Cristina Magi-Galluzzi, and Chin-Chen Pan, and Hemamali Samaratunga, and John R Srigley, and Lawrence True, and Ming Zhou, and Mark Clements, and Brett Delahunt, and

Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden.

OBJECTIVE Despite efforts to standardize histopathology practice through the development of guidelines, the interpretation of morphology is still hampered by subjectivity. We here describe Pathology Imagebase, a novel mechanism for establishing an international standard for the interpretation of pathology specimens. RESULTS The International Society of Urological Pathology (ISUP) established a reference image database through the input of experts in the field. Three panels were formed, one each for prostate, urinary bladder and renal pathology, consisting of 24 international experts. Each of the panel members uploaded microphotographs of cases into a non-public database. The remaining 23 experts were asked to vote from a multiple-choice menu. Prior to and while voting, panel members were unable to access the results of voting by the other experts. When a consensus level of at least two-thirds or 16 votes was reached, cases were automatically transferred to the main database. Consensus was reached in a total of 287 cases across five projects on the grading of prostate, bladder and renal cancer and the classification of renal tumours and flat lesions of the bladder. The full database is available to all ISUP members at www.isupweb.org. Non-members may access a selected number of cases. CONCLUSIONS It is anticipated that the database will assist pathologists in calibrating their grading, and will also promote consistency in the diagnosis of difficult cases.

UI	MeSH Term	Description	Entries
D010336	Pathology	A specialty concerned with the nature and cause of disease as expressed by changes in cellular or tissue structure and function caused by the disease process.	Pathologies
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D014571	Urologic Neoplasms	Tumors or cancer of the URINARY TRACT in either the male or the female.	Cancer of Urinary Tract,Urinary Tract Cancer,Urologic Cancer,Cancer of the Urinary Tract,Neoplasms, Urologic,Urinary Tract Neoplasms,Urological Cancer,Urological Neoplasms,Cancer, Urinary Tract,Cancer, Urologic,Cancer, Urological,Cancers, Urinary Tract,Cancers, Urologic,Cancers, Urological,Neoplasm, Urinary Tract,Neoplasm, Urologic,Neoplasm, Urological,Neoplasms, Urinary Tract,Neoplasms, Urological,Tract Neoplasm, Urinary,Tract Neoplasms, Urinary,Urinary Tract Cancers,Urinary Tract Neoplasm,Urologic Cancers,Urologic Neoplasm,Urological Cancers,Urological Neoplasm
D014572	Urology	A surgical specialty concerned with the study, diagnosis, and treatment of diseases of the urinary tract in both sexes, and the genital tract in the male. Common urological problems include urinary obstruction, URINARY INCONTINENCE, infections, and UROGENITAL NEOPLASMS.
D016208	Databases, Factual	Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.	Databanks, Factual,Data Banks, Factual,Data Bases, Factual,Data Bank, Factual,Data Base, Factual,Databank, Factual,Database, Factual,Factual Data Bank,Factual Data Banks,Factual Data Base,Factual Data Bases,Factual Databank,Factual Databanks,Factual Database,Factual Databases