Biomaterial Database

Residual effects of zopiclone and benzodiazepine hypnotics on psychomotor performance related to car driving. 1985

C Harrison, and Z Subhan, and I Hindmarch

A double-blind, randomized, cross-over study was carried out in 10 normal healthy volunteers to investigate the residual effects of 7.5 mg zopiclone, 1 mg lormetazepam, 0.25 mg triazolam, 1 mg flunitrazepam and placebo. Tests of psychomotor performance and analogues of car driving ability were administered the morning following night-time medication. Changes with respect to placebo in an information-processing task one hour after taking the medications confirmed the hypnotic efficacy of zopiclone, triazolam and flunitrazepam. Flunitrazepam also produced a significant depression of the Critical Flicker Fusion Threshold (CFF) and increased subjective ratings of sedation one hour after nocturnal dosing. Flunitrazepam impaired the reaction time on the information-processing test the morning following doses of 1 mg.

UI	MeSH Term	Description	Entries
D010879	Piperazines	Compounds that are derived from PIPERAZINE.
D011597	Psychomotor Performance	The coordination of a sensory or ideational (cognitive) process and a motor activity.	Perceptual Motor Performance,Sensory Motor Performance,Visual Motor Coordination,Coordination, Visual Motor,Coordinations, Visual Motor,Motor Coordination, Visual,Motor Coordinations, Visual,Motor Performance, Perceptual,Motor Performance, Sensory,Motor Performances, Perceptual,Motor Performances, Sensory,Perceptual Motor Performances,Performance, Perceptual Motor,Performance, Psychomotor,Performance, Sensory Motor,Performances, Perceptual Motor,Performances, Psychomotor,Performances, Sensory Motor,Psychomotor Performances,Sensory Motor Performances,Visual Motor Coordinations
D011897	Random Allocation	A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.	Randomization,Allocation, Random
D011930	Reaction Time	The time from the onset of a stimulus until a response is observed.	Response Latency,Response Speed,Response Time,Latency, Response,Reaction Times,Response Latencies,Response Times,Speed, Response,Speeds, Response
D004311	Double-Blind Method	A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.	Double-Masked Study,Double-Blind Study,Double-Masked Method,Double Blind Method,Double Blind Study,Double Masked Method,Double Masked Study,Double-Blind Methods,Double-Blind Studies,Double-Masked Methods,Double-Masked Studies,Method, Double-Blind,Method, Double-Masked,Methods, Double-Blind,Methods, Double-Masked,Studies, Double-Blind,Studies, Double-Masked,Study, Double-Blind,Study, Double-Masked
D005260	Female		Females
D005425	Flicker Fusion	The point or frequency at which all flicker of an intermittent light stimulus disappears.	Flicker Fusions,Fusion, Flicker,Fusions, Flicker
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D001334	Automobile Driving	The effect of environmental or physiological factors on the driver and driving ability. Included are driving fatigue, and the effect of drugs, disease, and physical disabilities on driving.	Automobile Drivings,Driving, Automobile,Drivings, Automobile