BIOMAT Database Logo BIOMAT Database Logo

Bioavailable and free 25-hydroxyvitamin D and vitamin D binding protein in polycystic ovary syndrome: Relationships with obesity and insulin resistance. 2018

Negar Naderpoor, and Soulmaz Shorakae, and Sally K Abell, and Aya Mousa, and Anju E Joham, and Lisa J Moran, and Nigel K Stepto, and Poli Mara Spritzer, and Helena J Teede, and Barbora de Courten
Monash Centre for Health Research and Implementation, School of Public health and Preventive Medicine, Monash University, Melbourne, Australia; Diabetes and Vascular Medicine Unit, Monash Health, Melbourne, Australia.

Polycystic ovary syndrome (PCOS) is a common condition characterised by both reproductive and metabolic features (obesity, insulin resistance, diabetes risk). Some evidence suggests that women with PCOS have lower vitamin D levels compared to healthy controls. Vitamin D binding protein (DBP) is the main carrier of vitamin D in circulation and plays an important role in regulating vitamin D concentration and bioavailability for target tissues. To our knowledge, no previous studies have examined DBP, bioavailable and free 25-hydroxyvitamin D (25(OH)D) in women with PCOS. The primary aim of this study was to compare DBP, bioavailable and free 25(OH)D concentrations in women with PCOS and controls. The secondary aim was to investigate relationships between DBP, bioavailable and free 25(OH)D and metabolic features (anthropometric measures, insulin resistance, and lipid profile). In a cross sectional study using bio-banked samples, we measured 25(OH)D, DBP and albumin. Bioavailable and free 25(OH)D were calculated using previously validated formula. BMI, body composition (dual X-ray absorptiometry, DXA), insulin resistance (homeostatic model assessment of insulin resistance (HOMA-IR)) and glucose infusion rate (GIR) from hyperinsulinaemic euglycaemic clamp and serum lipids (ELISA) were also measured in a physically and biochemically well-characterised cohort of women with and without PCOS. We studied 90 women with PCOS and 59 controls aged 18-48 years. DBP concentrations were lower in PCOS compared to controls (median [IQR]: 443.40 [314.4] vs 482.4 [156.8] μg/ml, p=0.02). No significant differences were found in bioavailable or free 25(OH)D concentrations between groups. DBP was not associated with BMI, percent body fat or markers of insulin resistance (all p>0.2). High-density lipoprotein (HDL) was the main determinant of DBP in the overall cohort (β=-0.12, p=0.02), after adjusting for covariates including PCOS/control status, age, BMI, total 25(OH)D and HOMA-IR. In PCOS, total and free 25(OH)D were related to markers of insulin resistance and lipids. Only the associations between free 25(OH)D and triglycerides (p=0.02), and HDL (p=0.03) remained significant after adjusting for age and BMI. In conclusion, women with PCOS had lower DBP, but similar bioavailable or free 25(OH)D concentrations compared to controls, independent of BMI and age. DBP was not associated with insulin resistance or BMI in PCOS. Further studies are needed to investigate the pathophysiology and clinical implications of reduced DBP in PCOS.

UI MeSH Term Description Entries
D007328 Insulin A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1). Iletin,Insulin A Chain,Insulin B Chain,Insulin, Regular,Novolin,Sodium Insulin,Soluble Insulin,Chain, Insulin B,Insulin, Sodium,Insulin, Soluble,Regular Insulin
D007333 Insulin Resistance Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS. Insulin Sensitivity,Resistance, Insulin,Sensitivity, Insulin
D008055 Lipids A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed) Lipid
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009765 Obesity A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
D011085 Polycystic Ovary Syndrome A complex disorder characterized by infertility, HIRSUTISM; OBESITY; and various menstrual disturbances such as OLIGOMENORRHEA; AMENORRHEA; ANOVULATION. Polycystic ovary syndrome is usually associated with bilateral enlarged ovaries studded with atretic follicles, not with cysts. The term, polycystic ovary, is misleading. Stein-Leventhal Syndrome,Polycystic Ovarian Syndrome,Polycystic Ovary Syndrome 1,Sclerocystic Ovarian Degeneration,Sclerocystic Ovaries,Sclerocystic Ovary Syndrome,Ovarian Degeneration, Sclerocystic,Ovarian Syndrome, Polycystic,Ovary Syndrome, Polycystic,Ovary, Sclerocystic,Sclerocystic Ovary,Stein Leventhal Syndrome,Syndrome, Polycystic Ovary,Syndrome, Stein-Leventhal
D001786 Blood Glucose Glucose in blood. Blood Sugar,Glucose, Blood,Sugar, Blood
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths

Related Publications

Negar Naderpoor, and Soulmaz Shorakae, and Sally K Abell, and Aya Mousa, and Anju E Joham, and Lisa J Moran, and Nigel K Stepto, and Poli Mara Spritzer, and Helena J Teede, and Barbora de Courten
Low serum 25-hydroxyvitamin D concentrations are associated with insulin resistance and obesity in women with polycystic ovary syndrome.
November 2006, Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association,
Negar Naderpoor, and Soulmaz Shorakae, and Sally K Abell, and Aya Mousa, and Anju E Joham, and Lisa J Moran, and Nigel K Stepto, and Poli Mara Spritzer, and Helena J Teede, and Barbora de Courten
Impact of 25-hydroxyvitamin D, free and bioavailable fractions of vitamin D, and vitamin D binding protein levels on metabolic syndrome components.
June 2017, Archives of medical science : AMS,
Negar Naderpoor, and Soulmaz Shorakae, and Sally K Abell, and Aya Mousa, and Anju E Joham, and Lisa J Moran, and Nigel K Stepto, and Poli Mara Spritzer, and Helena J Teede, and Barbora de Courten
Changes of Vitamin D-Binding Protein, and Total, Bioavailable, and Free 25-Hydroxyvitamin D in Transgender People.
July 2019, The Journal of clinical endocrinology and metabolism,
Negar Naderpoor, and Soulmaz Shorakae, and Sally K Abell, and Aya Mousa, and Anju E Joham, and Lisa J Moran, and Nigel K Stepto, and Poli Mara Spritzer, and Helena J Teede, and Barbora de Courten
Vitamin D in polycystic ovary syndrome: Relationship to obesity and insulin resistance.
January 2016, Molecular nutrition & food research,
Negar Naderpoor, and Soulmaz Shorakae, and Sally K Abell, and Aya Mousa, and Anju E Joham, and Lisa J Moran, and Nigel K Stepto, and Poli Mara Spritzer, and Helena J Teede, and Barbora de Courten
Circulating vitamin D binding protein, total, free and bioavailable 25-hydroxyvitamin D and risk of colorectal cancer.
January 2015, Scientific reports,
Negar Naderpoor, and Soulmaz Shorakae, and Sally K Abell, and Aya Mousa, and Anju E Joham, and Lisa J Moran, and Nigel K Stepto, and Poli Mara Spritzer, and Helena J Teede, and Barbora de Courten
Distribution and Determinants of Vitamin D-Binding Protein, Total, "Non-Bioavailable", Bioavailable, and Free 25-Hydroxyvitamin D Concentrations among Older Adults.
November 2021, Nutrients,
Negar Naderpoor, and Soulmaz Shorakae, and Sally K Abell, and Aya Mousa, and Anju E Joham, and Lisa J Moran, and Nigel K Stepto, and Poli Mara Spritzer, and Helena J Teede, and Barbora de Courten
Measured free 25-hydroxyvitamin D in healthy children and relationship to total 25-hydroxyvitamin D, calculated free 25-hydroxyvitamin D and vitamin D binding protein.
November 2018, Clinical biochemistry,
Negar Naderpoor, and Soulmaz Shorakae, and Sally K Abell, and Aya Mousa, and Anju E Joham, and Lisa J Moran, and Nigel K Stepto, and Poli Mara Spritzer, and Helena J Teede, and Barbora de Courten
25-Hydroxyvitamin D, Vitamin D Binding Protein, Bioavailable 25-Hydroxyvitamin D, and Body Composition in a Diverse Sample of Women Collegiate Indoor Athletes.
May 2020, Journal of functional morphology and kinesiology,
Negar Naderpoor, and Soulmaz Shorakae, and Sally K Abell, and Aya Mousa, and Anju E Joham, and Lisa J Moran, and Nigel K Stepto, and Poli Mara Spritzer, and Helena J Teede, and Barbora de Courten
Genetic variant in vitamin D-binding protein is associated with metabolic syndrome and lower 25-hydroxyvitamin D levels in polycystic ovary syndrome: A cross-sectional study.
January 2017, PloS one,
Negar Naderpoor, and Soulmaz Shorakae, and Sally K Abell, and Aya Mousa, and Anju E Joham, and Lisa J Moran, and Nigel K Stepto, and Poli Mara Spritzer, and Helena J Teede, and Barbora de Courten
Relations between obesity, insulin resistance, and 25-hydroxyvitamin D.
May 2012, The American journal of clinical nutrition,
Copied contents to your clipboard!