-transparent.png){kind=logo}
We report the occurrence in pigeon erythrocytes of a soluble Ca2+-dependent transglutaminase (TGase) activity. The effect of the erythrocyte ghost protein modifications, determined by TGase-catalyzed reactions, on adenylate cyclase, phospholipid methyltransferase I and II activities and on the lipidic matrix fluidity of the membrane was investigated by using a purified guinea pig liver TGase preparation. The results showed a significant inhibitory effect of such modifications both on the basal and on the variously stimulated (by NaF, Gpp(NH)p alone or in the presence of 1-isoproterenol) adenylate cyclase activity. By contrast, both the phospholipid methylation and the fluidity of the lipidic matrix of the membrane were unaffected by TGase-mediated reactions. These data suggest a new possible inhibitory mechanism of the cyclic AMP synthesis which might be triggered by the enhancement of the cytosolic Ca2+ concentration.
R Porta, and
A De Santis, and
C Esposito, and
G F Draetta, and
A Di Donato, and
G Illiano
March 1975,
The Journal of biological chemistry,
R Porta, and
A De Santis, and
C Esposito, and
G F Draetta, and
A Di Donato, and
G Illiano
January 1976,
Advances in enzyme regulation,
R Porta, and
A De Santis, and
C Esposito, and
G F Draetta, and
A Di Donato, and
G Illiano
May 1974,
The Journal of biological chemistry,
R Porta, and
A De Santis, and
C Esposito, and
G F Draetta, and
A Di Donato, and
G Illiano
January 1976,
Advances in prostaglandin and thromboxane research,
R Porta, and
A De Santis, and
C Esposito, and
G F Draetta, and
A Di Donato, and
G Illiano
May 1980,
The Journal of biological chemistry,
R Porta, and
A De Santis, and
C Esposito, and
G F Draetta, and
A Di Donato, and
G Illiano
November 1981,
Molecular pharmacology,
R Porta, and
A De Santis, and
C Esposito, and
G F Draetta, and
A Di Donato, and
G Illiano
December 1975,
Biochemical and biophysical research communications,
R Porta, and
A De Santis, and
C Esposito, and
G F Draetta, and
A Di Donato, and
G Illiano
January 1990,
Life sciences,
R Porta, and
A De Santis, and
C Esposito, and
G F Draetta, and
A Di Donato, and
G Illiano
August 1981,
Biochemical and biophysical research communications,
R Porta, and
A De Santis, and
C Esposito, and
G F Draetta, and
A Di Donato, and
G Illiano
July 1977,
Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie,
